Paper · 2026 · Natural Product Research

Isolation, characterisation and evaluation of pharmacological activity of Santalum album L. seed oil

Babu UV; Laxman S. Sawant; Sameer Pai; et al.

8
claims
16
verbatim quotes
0
citations
3
research areas
—
Not open access

Abstract

Santalum album L. of Santalaceae family is one of the most valuable plant species, native to Southern India. The crop is valued for its heartwood oil because of its sweet, fragrant aroma and fixative property. On the other hand, the seeds are underutilised and not much explored. The present study aims at profiling the fatty acid composition and evaluation of anti-inflammatory, antioxidant and Tyrosinase inhibitory activities. Sandal seeds reported 23% (v/w) of fixed oil with n-hexane as an extraction medium. The major fatty acids in sandal seed oil are reported as palmitic acid (2.028%), oleic acid (9.87%) and ximenynic acid (79.58%). ximenynic acid isolated by crystallisation method was validated through Gas chromatography and NMR analysis. The sandal seed oil and ximenynic acid displayed promising anti-inflammatory, antioxidant and Tyrosinase inhibitory activity. Sandal seeds can thus be utilised as the natural and sustainable source for cosmeceutical applications.

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Claims 8

Observationobservedoriginal resultmeasured

Claim · model-written summary

Sandal seeds yielded 23% fixed oil with n-hexane.

Taxon
Santalum album L.Santalum albumt0
Outcome
fixed oile0
Value
23% (v/w)e0
Qualifier
n-hexane as an extraction mediume0

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Santalum album
Santalum album · Taxon葉子 · CC0 · iNaturalist ↗

Verbatim

e0

“Sandal seeds reported 23% (v/w) of fixed oil with n-hexane as an extraction medium.”

✓ located verbatim in the source · abstract, characters 430–513 · show in text ↑
t0

“Santalum album L.”

✓ located verbatim in the source · title, characters 74–91 · show in text ↑
Observationobservedoriginal resultmeasured

Claim · model-written summary

Palmitic acid made up 2.028% of sandal seed oil.

Taxon
Santalum album L.Santalum albumt0
Outcome
palmitic acide0
Value
2.028%e0

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Santalum album
Santalum album · Taxon葉子 · CC0 · iNaturalist ↗

Verbatim

e0

“palmitic acid (2.028%)”

✓ located verbatim in the source · abstract, characters 571–593 · show in text ↑
t0

“Santalum album L.”

✓ located verbatim in the source · title, characters 74–91 · show in text ↑
Observationobservedoriginal resultmeasured

Claim · model-written summary

Oleic acid made up 9.87% of sandal seed oil.

Taxon
Santalum album L.Santalum albumt0
Outcome
oleic acide0
Value
9.87%e0

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Santalum album
Santalum album · Taxon葉子 · CC0 · iNaturalist ↗

Verbatim

e0

“oleic acid (9.87%)”

✓ located verbatim in the source · abstract, characters 595–613 · show in text ↑
t0

“Santalum album L.”

✓ located verbatim in the source · title, characters 74–91 · show in text ↑
Observationobservedoriginal resultmeasured

Claim · model-written summary

Ximenynic acid made up 79.58% of sandal seed oil.

Taxon
Santalum album L.Santalum albumt0
Outcome
ximenynic acide0
Value
79.58%e0

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Santalum album
Santalum album · Taxon葉子 · CC0 · iNaturalist ↗

Verbatim

e0

“ximenynic acid (79.58%)”

✓ located verbatim in the source · abstract, characters 618–641 · show in text ↑
t0

“Santalum album L.”

✓ located verbatim in the source · title, characters 74–91 · show in text ↑
Method / resourceobservedoriginal resultmeasured

Claim · model-written summary

Crystallized ximenynic acid was validated by chromatography and NMR.

Taxon
Santalum album L.Santalum albumt0
Outcome
ximenynic acid isolated by crystallisation methode0
Value
Gas chromatography and NMR analysise0

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Santalum album
Santalum album · Taxon葉子 · CC0 · iNaturalist ↗

Verbatim

e0

“ximenynic acid isolated by crystallisation method was validated through Gas chromatography and NMR analysis.”

✓ located verbatim in the source · abstract, characters 643–751 · show in text ↑
t0

“Santalum album L.”

✓ located verbatim in the source · title, characters 74–91 · show in text ↑
Observationobservedoriginal resultpositivemeasured

Claim · model-written summary

Sandal seed oil showed anti-inflammatory, antioxidant and Tyrosinase inhibitory activity.

Taxon
Santalum album L.Santalum albumt0
Material
sandal seed oile0
Outcome
anti-inflammatory, antioxidant and Tyrosinase inhibitory activitye0

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Santalum album
Santalum album · Taxon葉子 · CC0 · iNaturalist ↗

Verbatim

e0

“The sandal seed oil and ximenynic acid displayed promising anti-inflammatory, antioxidant and Tyrosinase inhibitory activity.”

✓ located verbatim in the source · abstract, characters 752–877 · show in text ↑
t0

“Santalum album L.”

✓ located verbatim in the source · title, characters 74–91 · show in text ↑
Observationobservedoriginal resultpositivemeasured

Claim · model-written summary

Ximenynic acid showed anti-inflammatory, antioxidant and Tyrosinase inhibitory activity.

Taxon
Santalum album L.Santalum albumt0
Outcome
anti-inflammatory, antioxidant and Tyrosinase inhibitory activitye0
Qualifier
ximenynic acide0

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Santalum album
Santalum album · Taxon葉子 · CC0 · iNaturalist ↗

Verbatim

e0

“The sandal seed oil and ximenynic acid displayed promising anti-inflammatory, antioxidant and Tyrosinase inhibitory activity.”

✓ located verbatim in the source · abstract, characters 752–877 · show in text ↑
t0

“Santalum album L.”

✓ located verbatim in the source · title, characters 74–91 · show in text ↑
Recommendationauthor interpretationoriginal resultbasis n/a

Claim · model-written summary

The authors suggest sandal seeds as a cosmeceutical source.

Taxon
Santalum album L.Santalum albumt0
Outcome
utilised as the natural and sustainable source for cosmeceutical applicationse0

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Santalum album
Santalum album · Taxon葉子 · CC0 · iNaturalist ↗

Verbatim

e0

“Sandal seeds can thus be utilised as the natural and sustainable source for cosmeceutical applications.”

✓ located verbatim in the source · abstract, characters 878–981 · show in text ↑
t0

“Santalum album L.”

✓ located verbatim in the source · title, characters 74–91 · show in text ↑