Abstract
Isodon rubescens is a widely used traditional folk medicine in China. In this study, 13 natural products were isolated using a two-step ethanol extraction. Notably, flavonoid glycosides 2 and 4, and polymeric caffeic acids 7 and 8, were identified for the first time from the secondary extraction residues, highlighting the continued presence of bioactive compounds with potential for further development. Oridonin (9), the major active compound, was quantified in nine commercial preparations using quantitative NMR (qNMR). Its concentration in the drop pill (0.92 mg/g) was comparable to that in the raw extract (0.90 mg/g). The three tablet samples showed varying levels: Tablet 3 (2.66 mg/g) > Tablet 1 (1.22 mg/g) > Tablet 2 (1.09 mg/g). Capsule, tea bag, and syrup samples could not be quantified due to low concentrations.
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Claims 8
Claim · model-written summary
Thirteen natural products were isolated from Isodon rubescens.
- Taxon
- Isodon rubescens
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Isodon rubescenst0 - Outcome
- natural products were isolatede0
- Value
- 13e0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
.jpg?width=500)
Verbatim
e0“13 natural products were isolated using a two-step ethanol extraction.”
t0“Isodon rubescens”
Claim · model-written summary
Flavonoid glycosides 2 and 4 were identified for the first time from secondary extraction residues.
- Taxon
- Isodon rubescensIsodon rubescenst0
- Outcome
- flavonoid glycosides 2 and 4e0
- Qualifier
- identified for the first time from the secondary extraction residuese0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“flavonoid glycosides 2 and 4, and polymeric caffeic acids 7 and 8, were identified for the first time from the secondary extraction residues”
t0“Isodon rubescens”
Claim · model-written summary
Polymeric caffeic acids 7 and 8 were identified for the first time from secondary extraction residues.
- Taxon
- Isodon rubescensIsodon rubescenst0
- Outcome
- polymeric caffeic acids 7 and 8e0
- Qualifier
- identified for the first time from the secondary extraction residuese0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“polymeric caffeic acids 7 and 8, were identified for the first time from the secondary extraction residues”
t0“Isodon rubescens”
Claim · model-written summary
Drop-pill oridonin concentration was 0.92 mg/g, comparable to raw extract.
- Taxon
- Isodon rubescensIsodon rubescenst0
- Outcome
- Oridonine1
- Value
- 0.92 mg/ge0
- Qualifier
- 0.90 mg/ge0
- Comparator
- raw extracte0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Its concentration in the drop pill (0.92 mg/g) was comparable to that in the raw extract (0.90 mg/g).”
e1“Oridonin (9), the major active compound”
t0“Isodon rubescens”
Claim · model-written summary
Tablet 3 oridonin concentration was 2.66 mg/g.
- Taxon
- Isodon rubescensIsodon rubescenst0
- Material
- Tablet 3e0
- Outcome
- Oridonine1
- Value
- 2.66 mg/ge0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Tablet 3 (2.66 mg/g) > Tablet 1 (1.22 mg/g) > Tablet 2 (1.09 mg/g)”
e1“Oridonin (9), the major active compound”
t0“Isodon rubescens”
Claim · model-written summary
Tablet 1 oridonin concentration was 1.22 mg/g.
- Taxon
- Isodon rubescensIsodon rubescenst0
- Material
- Tablet 1e0
- Outcome
- Oridonine1
- Value
- 1.22 mg/ge0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Tablet 3 (2.66 mg/g) > Tablet 1 (1.22 mg/g) > Tablet 2 (1.09 mg/g)”
e1“Oridonin (9), the major active compound”
t0“Isodon rubescens”
Claim · model-written summary
Tablet 2 oridonin concentration was 1.09 mg/g.
- Taxon
- Isodon rubescensIsodon rubescenst0
- Material
- Tablet 2e0
- Outcome
- Oridonine1
- Value
- 1.09 mg/ge0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Tablet 3 (2.66 mg/g) > Tablet 1 (1.22 mg/g) > Tablet 2 (1.09 mg/g)”
e1“Oridonin (9), the major active compound”
t0“Isodon rubescens”
Claim · model-written summary
Oridonin could not be quantified in capsule, tea bag and syrup samples because concentrations were low.
- Taxon
- Isodon rubescensIsodon rubescenst0
- Outcome
- Oridonine1
- Qualifier
- could not be quantified due to low concentrationse0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Capsule, tea bag, and syrup samples could not be quantified due to low concentrations.”
e1“Oridonin (9), the major active compound”
t0“Isodon rubescens”