Claim · model-written summary
Papaucin showed moderate positive in vitro activity against Entamoeba histolytica with an IC50 of 63.07.
- Taxon
- Annona diversifolia
Annona diversifoliat0 - Interactor
- Entamoeba histolytica
Entamoeba histolyticae1other - Outcome
- IC 50 valuese0
- Value
- 63.07e0
Verbatim
t0“Annona diversifolia”
e0“IC 50 values of 63.07 and 67.62 μg mL −1”
e1“Entamoeba histolytica”
Title
Ulises Murrieta‐Dionicio; Fernando Calzada; Elizabeth Barbosa; et al. Magnetic Resonance in Chemistry 2025. doi:10.1002/mrc.70065
Other claims from this paper (5)
- Observation A new cycloheptapeptide, papaucin, was obtained from the hydroethanolic extract of Annona diversifolia seeds.
- Observation Papaucin showed moderate positive in vitro activity against Giardia lamblia with an IC50 of 67.62 μg/mL.
- Observation In silico studies showed a higher affinity of papaucin for the PFOR enzyme than metronidazole.
- Observation In silico studies showed that papaucin also has affinity for the ALR enzyme, at a binding site different from the main catalytic site.
- Mechanism The authors suggest papaucin could exert its antiprotozoal effect through multiple mechanisms.