Claim · model-written summary
Compounds 1, 2, 4 and 7 from T. orientalis and compounds 9 and 10 from T. patriciae showed high efficacy against IBDV, with infected embryos surviving and having mean weights comparable to uninfected ones.
- Taxon
- Toussantia orientalise1
- Treatment
- aminocinnamoyl tetraketides 1, 2, and 4, glucosylflavonoid 7 from T. orientalis and ursolic acid derivatives 9 and 10 from T. patriciaee2
- Interactor
- Infectious Bursal Disease VirusInfectious bursal disease viruse1pathogen
- Outcome
- efficacy against IBDVe2
- Direction
- high efficacye2
- Comparator
- uninfected onese2
Verbatim
e1“The chemical constituents of Toussantia orientalis and T. patriciae (Annonaceae) leaf extracts were evaluated for their antiviral activities in ovo against Infectious Bursal Disease Virus (IBDV) and Newcastle Disease Virus (NDV)”
e2“Embryos infected with IBDV survived, grew to normal size with complete organ formation and had mean weights comparable to those of the uninfected ones when treated with the aminocinnamoyl tetraketides 1, 2, and 4, glucosylflavonoid 7 from T. orientalis and ursolic acid derivatives 9 and 10 from T. patriciae demonstrating high efficacy against IBDV”
Title
SS Nyandoro; MHH Nkunya; JC Cosam; et al. International Journal of Biological and Chemical Sciences 2014. doi:10.4314/ijbcs.v8i3.43
Other claims from this paper (3)
- Intervention effect Leaf constituents of Toussantia showed antiviral activity against NDV, reducing viral titre to 1:16 - 1:256 in the haemagglutination test.
- Intervention effect Compound 11 had the lowest NDV titre value (1:16), followed by compound 7 (1:32).
- Recommendation Compounds with significant antiviral efficacy could be considered potential leads for antiviral agent development.