Claim · model-written summary
IC50 for the methanol extract was 129.94 μg/mL, the lowest of the extracts.
- Taxon
- Kirkia wilmsii
Kirkia wilmsiit0 - Outcome
- IC50 valuese1
- Value
- 129.94 μg/mLe1
- Qualifier
- for methanole1
Not reportedMaterialGeneCompoundOrgan / stageInteractorInteractor roleSecond interactorSecond interactor roleTreatmentComparatorSettingDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“IC50 values ranged from 129.94 μg/mL for methanol to 225.04 μg/mL for water”
t0“solvent extracts of Kirkia wilmsii tubers”
Title
Phytochemical and antioxidant properties of different solvent extracts of Kirkia wilmsii tubers
Kayini Chigayo; Paul Eanas Lesedi Mojapelo; Simon Mnyakeni-Moleele; et al. Asian Pacific Journal of Tropical Biomedicine 2016. doi:10.1016/j.apjtb.2016.10.004
Other claims from this paper (17)
- Intervention effect The highest extract yield of 52.9% was obtained using 80% methanol.
- Intervention effect The lowest extract yield of 7.3% was obtained using ethanol at 60 min.
- Observation Six of the 12 solvent extracts gave yields higher than 5%.
- Observation The other six solvent extracts gave yields less than 1%.
- Observation Total phenolic content of the extracts ranged from 45.32 to 122.84 mg gallic acid equivalent per gram.
- Observation The maximum total flavonoid content was recorded for the methanol extract, at 917.02 mg quercetin equivalent per gram.
- Observation The minimum total flavonoid content was recorded for the water extract, at 206.26 mg quercetin equivalent per gram.
- Intervention effect The methanol extract had significantly higher flavonoid content than all other extracts.
- Intervention effect The 80% methanol, methanol/chloroform/water and 60% methanol extracts had significantly higher yields than ethanol, methanol and water extracts.
- Intervention effect The scavenging profiles of K. wilmsii extracts were significantly lower than that of ascorbic acid.
- Observation IC50 for the water extract was 225.04 μg/mL.
- Observation An IC50 value of 56.52 μg/mL was obtained with ascorbic acid.
- Recommendation Ethanol, methanol, methanol/chloroform/water, 80% methanol, 60% methanol and water can be used as suitable phytochemical extraction solvents for K. wilmsii tubers.
- Observation The analysis showed high levels of phenolic compounds and flavonoids in the tubers.
- Mechanism Phenols and flavonoids could be responsible for the radical scavenging activity of the extracts.
- Observation Phytochemical screening confirmed the presence of phenolics, flavonoids and terpenoids.
- Observation Phytochemical screening confirmed the presence of tannins, cardenolide deoxy sugars and reducing sugars.