Intervention effectmodel-written summary

TaHsfC2a overexpression enhanced heat tolerance.

A claim from An ABF5b‐HsfA2h/HsfC2a‐NCED2b/POD4/HSP26 module integrates multiple signaling pathway to modulate heat stress tolerance in wheat · 2025

Intervention effectobservedoriginal resultpositivesignificant (as stated)measured

Claim · model-written summary

Taxon: wheatTriticum aestivumt0
Treatment: overexpression of TaHsfC2ae0
Gene: TaHsfC2ae0
Outcome: heat stress tolerancee0
Direction: enhancede0

Not reportedMaterialCompoundOrgan / stageInteractorInteractor roleSecond interactorSecond interactor roleComparatorSettingValueQualifier

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

*Triticum aestivum* · TaxonRasbak · CC BY-SA 3.0 · Wikimedia Commons ↗

Verbatim

e0
“overexpression of TaHsfC2a significantly enhanced heat stress tolerance”
✓ located verbatim in the source · abstract, characters 1077–1148

t0
“wheat”
✓ located verbatim in the source · title, characters 123–128

Title

An ABF5b‐HsfA2h/HsfC2a‐NCED2b/POD4/HSP26 module integrates multiple signaling pathway to modulate heat stress tolerance in wheat

Ji‐Tong Wei; Lei Zheng; Xiao‐Jun Ma; et al. Plant Biotechnology Journal 2025. doi:10.1111/pbi.70164

Other claims from this paper (10)

Observation TaHsfA2h responded positively to heat stress.
Intervention effect TaHsfA2h overexpression enhanced heat tolerance.
Intervention effect TaHsfA2h RNA interference constrained heat tolerance.
Intervention effect TaHsfA2h overexpression increased ABA and ROS pathway gene expression.
Mechanism TaABF5b can modulate TaHsfA2h expression.
Observation TaHsfA2h interacted with TaHsfC2a in vivo and in vitro.
Intervention effect TaHsfC2a knockout reduced heat tolerance.
Intervention effect TaHsfC2a enhanced TaHsfA2h regulatory activity.
Mechanism TaHsfA2h and TaHsfC2a co regulate TaNCED2B, TaPOD4 and TaHSP26 expression.
Mechanism The regulatory module positively regulates wheat heat tolerance.

Record rev-16538e9d3a0954897fada5673f527a93d96bf9bd636d46cd5ea5c6b69e7f39f8 · schema claims-v0.9 · position 7 in the model’s answer

Functional evidence on LOC123160579

Claims that state a gain or loss of function of this gene and what it did to a trait, compared with wild type or a control.

LOC123160579 · NCBI Gene 123160579 ↗ · Open in the knowledge graph

Triticum aestivum (wheat)1 paper · 1 traitTested in one paper only

Only one paper in the store tests this gene's function in Triticum aestivum (wheat).

Heat tolerance1 paper

Promotes
TaHsfC2a overexpression enhanced heat tolerance.
An ABF5b‐HsfA2h/HsfC2a‐NCED2b/POD4/HSP26 module integrates multiple signaling pathway to modulate heat stress tolerance in wheat · 2025
gain of function → more of the traitThis claim

The program reads each claim's manipulation and the direction of the trait, and from them the gene's role (gain and more, or loss and less, means it promotes the trait). Roles are read by program from each claim's wording. Pairs of papers on the same host, gene and trait were checked claim by claim by two model readers; a pair is marked checked only when both accept it. Gene layer v0.8, 21 trait classes.