Claim · model-written summary
ZmeIF4A3 sterically blocks ZmMTA-mediated m6A deposition, preventing viral RNA degradation.
Zea maysNot reportedMaterialCompoundOrgan / stageInteractorInteractor roleSecond interactorSecond interactor roleTreatmentComparatorSettingDirectionValue
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“sugarcane mosaic virus (SCMV), a prevalent potyvirus that infects maize”
e4“ZmeIF4A3 sterically blocks ZmMTA-mediated m6A deposition, thereby preventing viral RNA from degradation”
Title
Dezhi Peng; Laihua Dong; Pei Wang; et al. Nucleic Acids Research 2026. doi:10.1093/nar/gkaf1432
Other claims from this paper (6)
- Observation Maize ZmMTA deposits m6A at A6556 of the SCMV genomic RNA.
- Mechanism ZmECT23 directly recruits the ZmCCR4-NOT complex to facilitate viral RNA decay.
- Mechanism SCMV NIa-Pro hijacks maize ZmeIF4A3 into viral replication complexes.
- Observation Mechanistic conservation is observed in potato virus Y and turnip mosaic virus.
- Observation eIF4A3 is identified as a key m6A regulator in plants.
- Recommendation eIF4A3 is suggested as a potential target for engineering m6A-based antiviral crops.