Claim · model-written summary
The purified Arabidopsis complex contained all 11 subunits known from yeast SWR1 and mammalian SRCAP.
- Taxon
- Arabidopsis
Arabidopsist0 - Outcome
- all 11 subunitse0
Not reportedMaterialGeneCompoundOrgan / stageInteractorInteractor roleSecond interactorSecond interactor roleTreatmentComparatorSettingDirectionValueQualifier
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“We identified all 11 subunits found in yeast SWR1 and the homologous mammalian SRCAP complexes”
t0“Arabidopsis genome”
Title
Paja Sijacic; Dylan H. Holder; Marko Bajic; et al. PLoS Genetics 2019. doi:10.1371/journal.pgen.1008326
Other claims from this paper (9)
- Observation The complex also contained MBD9 and three Alfin1-like family proteins.
- Observation mbd9 mutant plants resembled arp6 mutants phenotypically.
- Mechanism MBD9 was needed for proper H2A.Z incorporation at thousands of discrete sites.
- Observation MBD9 preferentially interacted with acetylated H4 peptides and H3 peptides with specified methylation.
- Observation MBD9-dependent H2A.Z sites had a distinct histone modification profile.
- Mechanism MBD9 is proposed to recognize nucleosome modifications and guide SWR1 to H2A.Z deposition sites.
- Observation MBD9 did not appear to be a core Arabidopsis SWR1 subunit.
- Observation The arp6;mbd9 double mutant displayed a synergistic phenotype.
- Mechanism The authors infer that MBD9 also has roles beyond H2A.Z deposition.