Claim · model-written summary
The forward genetics pipeline was judged effective for identifying HIGS targets.
Not reportedTaxonMaterialGeneCompoundOrgan / stageInteractorInteractor roleSecond interactorSecond interactor roleTreatmentComparatorSettingValueQualifier
Verbatim
e0“our forward genetics gene discovery pipeline in S. sclerotiorum is highly effective in identifying novel HIGS targets to control S. sclerotiorum and B. cinerea”
Title
Yan Xu; Jinyi Tan; Junxing Lu; et al. Plant Biotechnology Journal 2023. doi:10.1111/pbi.14184
Other claims from this paper (7)
- Observation SsGAP1 is required for Sclerotinia sclerotia formation, appressoria production and virulence.
- Observation BcGAP1 has similar roles in fungal development and virulence.
- Observation SsRAS1 knockdown showed the gene is required for vegetative growth, sclerotia, appressoria and virulence.
- Observation SsRAS2 knockdown showed the gene is required for vegetative growth, sclerotia, appressoria and virulence.
- Intervention effect HIGS targeting SsGAP1 reduced fungal virulence in Nicotiana and Arabidopsis.
- Intervention effect HIGS targeting SsRAS1 reduced fungal virulence in Nicotiana and Arabidopsis.
- Intervention effect HIGS targeting SsRAS2 reduced fungal virulence in Nicotiana and Arabidopsis.