Claim · model-written summary
Compound P8 from P. striatus was described as a new natural product.
- Taxon
- P. striatusPtychanthus striatuse0
- Outcome
- compound P8e0
- Qualifier
- new natural producte0
Not reportedMaterialGeneCompoundOrgan / stageInteractorInteractor roleSecond interactorSecond interactor roleTreatmentComparatorSettingDirectionValue
Verbatim
e0“compound P8 from P. striatus is described as a new natural product.”
Title
Huy Truong Nguyen; Thi-Minh Dinh Tran; Thuc-Huy Duong; et al. Molecules 2026. doi:10.3390/molecules31122009
Other claims from this paper (8)
- Observation Thirteen compounds were isolated from Vitex rotundifolia.
- Observation Ten metabolites were obtained from Ptychanthus striatus.
- Observation Most isolated compounds were reported from these species for the first time.
- Observation Chrysoplenol D was the most potent SARS-CoV-2 Mpro inhibitor, with an IC50 of 0.08 ± 0.01 µM.
- Observation Selected phenolic and bibenzyl metabolites from P. striatus followed chrysoplenol D in inhibitory potency.
- Observation Other flavonoid derivatives from V. rotundifolia followed chrysoplenol D in inhibitory potency.
- Observation Most diterpenoids had weak or negligible protease inhibition.
- Observation Docking showed representative active compounds binding in the Mpro catalytic pocket and interacting with His41, Gly143, and Cys145.