Claim · model-written summary
The intergenic region promoted CP gene expression.
- Taxon
- plant virust0
- Gene
- capsid protein (CP)e0
- Outcome
- CP gene expressione0
- Qualifier
- intergenic region between the polymerase and capsid protein (CP)e0
Not reportedMaterialCompoundOrgan / stageInteractorInteractor roleSecond interactorSecond interactor roleTreatmentComparatorSettingDirectionValue
Verbatim
e0“The intergenic region between the polymerase and capsid protein (CP) acts as a promoter for CP gene expression.”
t0“plant virus”
Title
Mikhail Oliveira Leastro; Elliot Watanabe Kitajima; Vicente Pallas; et al. PLoS Pathogens 2025. doi:10.1371/journal.ppat.1013388
Other claims from this paper (15)
- Method / resource A recombinant GFP-expressing CiLV-C was feasible for cilevirus research.
- Observation Viral RNA1 was essential for replication and independently self-replicated.
- Observation Viral RNA2 was crucial for movement.
- Observation CP was critical for viral RNA accumulation.
- Observation Movement protein p32 facilitated viral spread.
- Intervention effect Deleting p61 did not affect virion assembly.
- Observation The putative matrix protein p24 was critical for virion morphogenesis.
- Intervention effect Deleting p15 attenuated disease symptoms.
- Intervention effect Deleting p15-p61 attenuated symptoms.
- Mechanism CP enhanced viral RNA accumulation independently of RSS.
- Observation CP bound RNA and interacted with eIF4A.
- Intervention effect Overexpressing eIF4A increased CiLV-C RNA accumulation.
- Intervention effect Knockdown of eIF4A reduced viral RNA accumulation.
- Observation Turnip crinkle virus showed similar results for eIF4A.
- Intervention effect TCV CP restored RNA accumulation in CP-defective CiLV-C.