Claim · model-written summary
HMA4 and its bacterial homolog had broadly conserved zinc pathways, with entrance-region differences.
- Taxon
- Arabidopsis thaliana
Arabidopsis thalianae1 - Gene
- HMA4e1
- Outcome
- zinc pathway displayed overall conservatione0
- Qualifier
- significant differencese0
Not reportedMaterialCompoundOrgan / stageInteractorInteractor roleSecond interactorSecond interactor roleTreatmentComparatorSettingDirectionValue
Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Verbatim
e0“Although the zinc pathway displayed overall conservation among the two proteins, significant differences were observed, especially in the entrance area with altered electronegativity and the presence of a ionic interaction/hydrogen bond network.”
e1“The P1B ATPase heavy metal ATPase 4 (HMA4) is responsible for zinc and cadmium translocation from roots to shoots in Arabidopsis thaliana.”
Title
Gilles Lekeux; Jean-Marc Crowet; Cécile Nouet; et al. Journal of Experimental Botany 2018. doi:10.1093/jxb/ery353
Other claims from this paper (4)
- Observation The pathway entrance differed in electronegativity and ionic or hydrogen-bond network.
- Intervention effect Newly identified amino acids lost all or some protein function when mutated.
- Observation HMA4 mutants differed in their zinc translocation ability.
- Observation HMA4 mutants differed in cadmium translocation ability.