Claim · model-written summary
Eight new chalcones were isolated from the aerial parts of Medicago sativa for the first time, together with 12 known chalcones.
- Taxon
- Medicago sativa
Medicago sativat0 - Organ / stage
- aerial partse1
- Outcome
- new chalconese1
Not reportedMaterialGeneCompoundInteractorInteractor roleSecond interactorSecond interactor roleTreatmentComparatorSettingDirectionValueQualifier
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“Characterization of Chalcones from Medicago sativa L.”
e1“A total of 8 new chalcones ( 1 – 8 ), and 12 known chalcones ( 9 – 20 ) were isolated from the aerial parts of M. sativa for the first time”
Title
Qin-Ge Ma; Ting Li; Rong-Rui Wei; et al. Journal of Agricultural and Food Chemistry 2016. doi:10.1021/acs.jafc.6b03883
Other claims from this paper (5)
- Intervention effect Compounds 3, 4, 11, 12 and 20 (10 μM) showed significant hypolipidemic activity, measured as triglyceride content in HepG2 cells, with simvastatin as the positive control.
- Intervention effect Compound 6, among compounds 6, 8, 18 and 19, inhibited VEGF-induced human umbilical vein endothelial cell proliferation in vitro, with an IC 50 of 13.86 ± 0.43 μM.
- Intervention effect Compound 8, among compounds 6, 8, 18 and 19, inhibited VEGF-induced human umbilical vein endothelial cell proliferation in vitro, with an IC 50 of 15.53 ± 0.19 μM.
- Intervention effect Compound 18, among compounds 6, 8, 18 and 19, inhibited VEGF-induced human umbilical vein endothelial cell proliferation in vitro, with an IC 50 of 39.52 ± 0.24 μM.
- Intervention effect Compound 19, among compounds 6, 8, 18 and 19, inhibited VEGF-induced human umbilical vein endothelial cell proliferation in vitro, with an IC 50 of 45.04 ± 0.51 μM.