Claim · model-written summary
Compound 4 from Eurya chinensis has potent cytotoxic activity, with IC50 values of 7.45 to 8.54 μM against human cancer cell lines.
- Taxon
- Eurya chinensis
Eurya chinensise0 - Compound
- Compound 4e3
- Outcome
- cytotoxic activitye3
- Value
- 7.45 to 8.54 μMe3
- Qualifier
- against human cancer cell lines NCI-H46, HepG2 and SW480e3
Not reportedMaterialGeneOrgan / stageInteractorInteractor roleSecond interactorSecond interactor roleTreatmentComparatorSettingDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Two new ent-kaurane diterpenes (1–2), together with five known analogs, were isolated from the stems of Eurya chinensis”
e3“Compound 4 showed potent cytotoxic activity against human cancer cell lines NCI-H46, HepG2 and SW480 with IC50 values ranging from 7.45 to 8.54 μM”
Title
Two new ent-kaurane diterpenes from the stems of Eurya chinensis
Jia-Ling Song; Yao Yuan; Ling-Hui Nie; et al. Journal of Asian Natural Products Research 2017. doi:10.1080/10286020.2017.1373099
Other claims from this paper (3)
- Observation Two new ent-kaurane diterpenes were isolated from Eurya chinensis stems, together with five known analogs.
- Observation Structures of the new compounds were established by MS and 1D and 2D NMR analysis.
- Observation Compound 3 from Eurya chinensis has noticeable anti-inflammatory activity, with an IC50 of 7.82 μM for inhibiting LPS-induced NO production in RAW264.7 cells.