Claim · model-written summary
Beclin1 interacted with TuMV NIb via the conserved GDD motif.
- Taxon
- plantsViridiplantaet0
- Interactor
- TuMV
Turnip mosaic viruse0pathogen - Gene
- Beclin1e0
- Outcome
- interacts with NIbe0
- Qualifier
- via the highly conserved GDD motife0
Not reportedMaterialCompoundOrgan / stageSecond interactorSecond interactor roleTreatmentComparatorSettingDirectionValue
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Beclin1 interacts with NIb, the RNA-dependent RNA polymerase (RdRp) of TuMV, via the highly conserved GDD motif”
t0“plants”
Title
Fangfang Li; Changwei Zhang; Yinzi Li; et al. Nature Communications 2018. doi:10.1038/s41467-018-03658-2
Other claims from this paper (8)
- Observation TuMV infection activated autophagy in plants.
- Mechanism Beclin1 inhibited virus replication.
- Mechanism The Beclin1–NIb complex was targeted for autophagic degradation, likely via ATG8a.
- Intervention effect Autophagy inhibitors inhibited Beclin1-mediated NIb degradation.
- Intervention effect Beclin1 deficiency enhanced NIb accumulation and viral infection.
- Intervention effect ATG8a deficiency enhanced NIb accumulation and viral infection.
- Intervention effect Overexpression of a Beclin1 truncation mutant inhibited virus replication.
- Observation Beclin1–RdRp interaction extended to several RNA viruses.