Claim · model-written summary
Thymoquinone was identified as one of the most bioactive compounds in the brine shrimp test of Monarda fistulosa fractions.
- Taxon
- Monarda fistulosa
Monarda fistulosae0 - Compound
- thymoquinonee1
- Outcome
- most bioactive compounds in the BSTe1
Not reportedMaterialGeneOrgan / stageInteractorInteractor roleSecond interactorSecond interactor roleTreatmentComparatorSettingDirectionValueQualifier
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Monarda fistulosa L. (Lamiaceae), also known as wild bergamot, was subjected to bioactivity-directed fractionation using the BST to identify the in vitro bioactive constituents”
e1“Purification of the F005 (partitioned fraction) sample yielded thymoquinone (C10H 12O2, MW164) and thymol (C10H14O, MW 150) as the most bioactive compounds in the BST”
Title
Holly A. Johnson Purdue e-Pubs (Purdue University System) 1998
Other claims from this paper (10)
- Association LC50 values from the brine shrimp test correlated with acetogenin concentration in Asimina triloba twigs.
- Observation May, June and July were the top three months for acetogenin production in Asimina triloba.
- Association Bioactivity of Asimina triloba twigs decreased by one to two orders of magnitude in late fall to winter.
- Association Bullatacin content in Asimina triloba twigs increased significantly in May and June, at 13 and 15 ppm.
- Association The mixture of asimicin and trilobacin in Asimina triloba twigs increased significantly in May and June, at 47 and 51 ppm.
- Observation Thymol was identified as one of the most bioactive compounds in the brine shrimp test of Monarda fistulosa fractions.
- Intervention effect Thymoquinone showed selective cytotoxicity towards the PC-3 prostate tumor cell line, with an ED50 comparable to Adriamycine.
- Observation Thymoquinone displayed interesting selectivities in the NCI 60 human tumor cell panel.
- Observation Thymol was not cytotoxic.
- Intervention effect Thymol showed pesticidal activity comparable to rotenone.