Abstract
Arabidopsis COP1 acts to repress photomorphogenesis in the absence of light. It was shown that in the dark, COP1 directly interacts with the bZIP transcription factor HY5, a positive regulator of photomorphogenesis, and promotes its proteasome-mediated degradation. Here we identify a novel bZIP protein HYH, as a new target of COP1. We identify a physical and genetic interaction between HYH and COP1 and show that this interaction results in dark-specific degradation of HYH. Genetic analysis indicates that HYH is predominantly involved in blue-light regulation of development and gene expression, and that the function of HYH in part overlaps with that of HY5. The accumulation of HYH protein, not the mRNA, is dependent on the presence of HY5. Our data suggest that HYH and HY5 can, respectively, act as heterodimers and homodimers, thus mediating light-regulated expression of overlapping as well as distinct target genes. We propose that COP1 mediates light control of gene expression through targeted degradation of multiple photomorphogenesis-promoting transcription factors in the nucleus.
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Claims 11
Claim · model-written summary
HYH was identified as a new COP1 target.
- Taxon
- Arabidopsis
Arabidopsise0 - Gene
- HYHe1
- Outcome
- a new target of COP1e1
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Arabidopsis COP1 acts to repress photomorphogenesis in the absence of light.”
e1“Here we identify a novel bZIP protein HYH, as a new target of COP1.”
Claim · model-written summary
HYH and COP1 physically and genetically interact.
- Taxon
- ArabidopsisArabidopsise0
- Gene
- HYH and COP1e1
- Outcome
- physical and genetic interactione1
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Arabidopsis COP1 acts to repress photomorphogenesis in the absence of light.”
e1“We identify a physical and genetic interaction between HYH and COP1”
Claim · model-written summary
The HYH-COP1 interaction results in dark-specific HYH degradation.
- Taxon
- ArabidopsisArabidopsise0
- Gene
- HYHe1
- Outcome
- dark-specific degradation of HYHe1
- Qualifier
- this interactione1
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Arabidopsis COP1 acts to repress photomorphogenesis in the absence of light.”
e1“this interaction results in dark-specific degradation of HYH”
Claim · model-written summary
HYH is predominantly involved in blue-light regulation of development and gene expression.
- Taxon
- ArabidopsisArabidopsise0
- Gene
- HYHe1
- Outcome
- blue-light regulation of development and gene expressione1
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Arabidopsis COP1 acts to repress photomorphogenesis in the absence of light.”
e1“HYH is predominantly involved in blue-light regulation of development and gene expression”
Claim · model-written summary
HYH function partly overlaps with HY5 function.
- Taxon
- ArabidopsisArabidopsise0
- Gene
- HYHe1
- Outcome
- function of HYH in part overlaps with that of HY5e1
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Arabidopsis COP1 acts to repress photomorphogenesis in the absence of light.”
e1“the function of HYH in part overlaps with that of HY5”
Claim · model-written summary
HYH protein accumulation depends on HY5 presence.
- Taxon
- ArabidopsisArabidopsise0
- Gene
- HY5e1
- Outcome
- accumulation of HYH proteine1
Not reportedDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Arabidopsis COP1 acts to repress photomorphogenesis in the absence of light.”
e1“The accumulation of HYH protein, not the mRNA, is dependent on the presence of HY5.”
Claim · model-written summary
HYH mRNA accumulation does not depend on HY5 presence.
- Taxon
- ArabidopsisArabidopsise0
- Gene
- HY5e1
- Outcome
- the mRNAe1
Not reportedDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Arabidopsis COP1 acts to repress photomorphogenesis in the absence of light.”
e1“The accumulation of HYH protein, not the mRNA, is dependent on the presence of HY5.”
Claim · model-written summary
The authors suggest that HYH and HY5 can act as heterodimers.
- Taxon
- ArabidopsisArabidopsise0
- Gene
- HYHe1
- Outcome
- heterodimerse1
- Qualifier
- Our data suggeste1
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Arabidopsis COP1 acts to repress photomorphogenesis in the absence of light.”
e1“Our data suggest that HYH and HY5 can, respectively, act as heterodimers and homodimers, thus mediating light-regulated expression of overlapping as well as distinct target genes.”
Claim · model-written summary
The authors suggest that HY5 can act as homodimers.
- Taxon
- ArabidopsisArabidopsise0
- Gene
- HY5e1
- Outcome
- homodimerse1
- Qualifier
- Our data suggeste1
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Arabidopsis COP1 acts to repress photomorphogenesis in the absence of light.”
e1“Our data suggest that HYH and HY5 can, respectively, act as heterodimers and homodimers, thus mediating light-regulated expression of overlapping as well as distinct target genes.”
Claim · model-written summary
The authors suggest that HYH and HY5 dimers mediate expression of overlapping and distinct light-regulated target genes.
- Taxon
- ArabidopsisArabidopsise0
- Outcome
- light-regulated expression of overlapping as well as distinct target genese1
- Qualifier
- thus mediatinge1
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Arabidopsis COP1 acts to repress photomorphogenesis in the absence of light.”
e1“thus mediating light-regulated expression of overlapping as well as distinct target genes.”
Claim · model-written summary
The authors propose COP1 controls light-regulated gene expression by degrading multiple transcription factors in the nucleus.
- Taxon
- ArabidopsisArabidopsise0
- Gene
- COP1e1
- Outcome
- light control of gene expressione1
- Qualifier
- targeted degradation of multiple photomorphogenesis-promoting transcription factors in the nucleuse1
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Arabidopsis COP1 acts to repress photomorphogenesis in the absence of light.”
e1“We propose that COP1 mediates light control of gene expression through targeted degradation of multiple photomorphogenesis-promoting transcription factors in the nucleus.”