Abstract
Studies on the chemical constituents of the aerial parts of Pterocaulon redolens (Forst.f)F. Vill.(Asteraceae) resulted in the isolation of ten components: seven coumarins [5-methoxy-6,7-methylenedioxycoumarin (1), ayapin (2), puberulin (3), 5-methoxyscopoletin (4), 2',3'-dihydroxypuberulin ( 5), isofraxidin (6), and 5-(2',3'-dihydroxy-3'-methylbutyloxy)-6, 7-methylenedioxycoumarin (7)] and three flavonoids [luteolin (8), tomentin (9), and chrysosplenol C (10)], among which 5 was firstly isolated as a natural product.The full 1 H-and 13 C-NMR spectral assignments for the isolated products, including revision of previous assignment in the literature are reported.Six coumarins (1-4, 6, and 7) and one flavonoid (8) displayed mild activity against Mycobacterium tuberculosis H 37 Ra.In addition, flavonoid (10) was firstly found to possess moderate cytotoxicity against breast cancer (BC) and human small cell lung cancer (NCI-H187) cell lines.
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Claims 6
Claim · model-written summary
Coumarin 2',3'-dihydroxypuberulin was isolated for the first time as a natural product from Pterocaulon redolens.
- Taxon
- Pterocaulon redolens
Pterocaulon redolense0 - Compound
- 2',3'-dihydroxypuberuline2
- Outcome
- firstly isolated as a natural producte1
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“Chemical Constituents of Pterocaulon redolens”
e0“Studies on the chemical constituents of the aerial parts of Pterocaulon redolens (Forst.f)F. Vill.(Asteraceae) resulted in the isolation of ten components”
e1“among which 5 was firstly isolated as a natural product”
e2“2',3'-dihydroxypuberulin ( 5)”
Claim · model-written summary
Ten components, seven coumarins and three flavonoids, were isolated from the aerial parts of Pterocaulon redolens.
- Taxon
- Pterocaulon redolensPterocaulon redolense0
- Organ / stage
- aerial partse0
- Outcome
- isolation of ten componentse0
- Value
- ten componentse0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“Chemical Constituents of Pterocaulon redolens”
e0“Studies on the chemical constituents of the aerial parts of Pterocaulon redolens (Forst.f)F. Vill.(Asteraceae) resulted in the isolation of ten components”
Claim · model-written summary
Full 1H- and 13C-NMR spectral assignments were reported for the isolated products, including a revision of a previous literature assignment.
- Taxon
- Pterocaulon redolensPterocaulon redolenst0
- Outcome
- NMR spectral assignmentse3
- Qualifier
- including revision of previous assignmente3
- Comparator
- previous assignment in the literaturee3
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“Chemical Constituents of Pterocaulon redolens”
e3“The full 1 H-and 13 C-NMR spectral assignments for the isolated products, including revision of previous assignment in the literature are reported”
Claim · model-written summary
Six coumarins (1-4, 6 and 7) displayed mild antimycobacterial activity against Mycobacterium tuberculosis H37Ra.
- Taxon
- Pterocaulon redolensPterocaulon redolenst0
- Interactor
- Mycobacterium tuberculosis
Mycobacterium tuberculosise4other - Compound
- Six coumarins (1-4, 6, and 7)e4
- Outcome
- mild activitye4
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“Chemical Constituents of Pterocaulon redolens”
e4“Six coumarins (1-4, 6, and 7) and one flavonoid (8) displayed mild activity against Mycobacterium tuberculosis H 37 Ra”
Claim · model-written summary
Flavonoid luteolin (8) displayed mild antimycobacterial activity against Mycobacterium tuberculosis H37Ra.
- Taxon
- Pterocaulon redolensPterocaulon redolenst0
- Interactor
- Mycobacterium tuberculosisMycobacterium tuberculosise4other
- Compound
- luteolin (8)e5
- Outcome
- mild activitye4
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“Chemical Constituents of Pterocaulon redolens”
e4“Six coumarins (1-4, 6, and 7) and one flavonoid (8) displayed mild activity against Mycobacterium tuberculosis H 37 Ra”
e5“luteolin (8), tomentin (9), and chrysosplenol C (10)”
Claim · model-written summary
Flavonoid chrysosplenol C (10) showed moderate cytotoxicity against breast cancer and human small cell lung cancer cell lines, reported as a first finding.
- Taxon
- Pterocaulon redolensPterocaulon redolenst0
- Compound
- chrysosplenol Ce5
- Outcome
- moderate cytotoxicitye6
- Qualifier
- breast cancer (BC) and human small cell lung cancer (NCI-H187) cell linese6
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“Chemical Constituents of Pterocaulon redolens”
e5“luteolin (8), tomentin (9), and chrysosplenol C (10)”
e6“flavonoid (10) was firstly found to possess moderate cytotoxicity against breast cancer (BC) and human small cell lung cancer (NCI-H187) cell lines”