Abstract
Bioactive compounds derived from plant natural compounds have proven to be valuable sources of metabolites which can seldom be obtained from other sources. Plants belonging to the genus Zanthoxylum have been valued across various cultures for their curative properties. Zanthoxylum armatum DC., belonging to the family Rutaceae is extensively used in traditional practices in North-Eastern India and neighbouring regions including South-East Asia. However, the potential cytogenetic effects of Zanthoxylum armatum under in vivo conditions, and their causative mechanisms have not yet been studied in detail. The current study was undertaken to evaluate the cytotoxic and genotoxic potential of aqueous extracts of fruits of Z. armatum under in vivo conditions using the Allium test. Physiological and cellular data indicate that the extracts induce clumped chromosomes at metaphase stage of cell division coupled with mitotic arrest. Electron microscopy data reveal membrane damage of cellular organelles, chromatin condensation and chromatin marginalisation in cell of roots incubated in the extracts. The extracts also induce concentration dependent protein precipitation and genomic DNA degradation.
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Claims 5
Claim · model-written summary
Extracts induced clumped metaphase chromosomes and mitotic arrest in Allium.
- Treatment
- Zanthoxylum armatumt0
_Allium_vineale_-_inflorescence_immature.jpg?width=60){kind=small}
AlliumNot reportedComparatorDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
_Allium_vineale_-_inflorescence_immature.jpg?width=500)
Verbatim
t0“Zanthoxylum armatum”
e0“using the Allium test.”
e1“the extracts induce clumped chromosomes at metaphase stage of cell division coupled with mitotic arrest.”
Claim · model-written summary
Extract exposure damaged cellular organelle membranes in Allium roots.
Not reportedComparatorDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“using the Allium test.”
e1“Electron microscopy data reveal membrane damage of cellular organelles, chromatin condensation and chromatin marginalisation in cell of roots incubated in the extracts.”
Claim · model-written summary
Extract exposure caused chromatin condensation and marginalisation in Allium root cells.
Not reportedComparatorDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“using the Allium test.”
e1“Electron microscopy data reveal membrane damage of cellular organelles, chromatin condensation and chromatin marginalisation in cell of roots incubated in the extracts.”
Claim · model-written summary
Extracts induced concentration-dependent protein precipitation.
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“using the Allium test.”
e1“The extracts also induce concentration dependent protein precipitation and genomic DNA degradation.”
Claim · model-written summary
Extracts induced genomic DNA degradation.
Not reportedComparatorDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“using the Allium test.”
e1“The extracts also induce concentration dependent protein precipitation and genomic DNA degradation.”
The same questions in other papers
botanical · physiology: oxidative · AlliumResults agree
1 paper in the same direction as this paper
- negative
Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.