Abstract
I. viscosa has been used for years in folk medicine for its anti-inflammatory, antipyretic, antiseptic, and paper antiphlogistic activities. In this study, cytotoxic and genotoxic effects of I. viscosa leaf extracts on the root meristem cells of Allium cepa have been examined. Onion bulbs were exposed to 2.5 mg/ml, 5 mg/ml, and 10 mg/ml concentrations of the extracts for macroscopic and microscopic analysis. Tap water has been used as a negative control and Ethyl methanesulfonate (EMS) (2 * 10(-2) M) has been used as a positive control. The test concentrations have been determined according to doses which are recommended for use in alternative medicine. There has been statistically significant (P < .05) inhibition of root growth depending on concentration by the extracts when compared with the control groups. All the tested extracts have been observed to have cytotoxic effects on cell division in A. cepa. I. viscosa leaf extract induces the total number of chromosomal aberrations and micronuclei (MNC) formations in A. cepa root tip cells significantly when compared with control groups. Also, this paper shows for the first time the induction of cell death, ghost cells, cells with membrane damage, and binucleated cells by extract treatment. These results suggest the cytotoxic and genotoxic effects of the I. viscosa leaf extracts on A. cepa.
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Claims 6
Claim · model-written summary
Extracts inhibited onion root growth significantly in a concentration-dependent manner.
_Allium_vineale_-_inflorescence_immature.jpg?width=60){kind=small}
AlliumOrganisms pictured · Representative pictures of the matched species, not figures from the paper.
_Allium_vineale_-_inflorescence_immature.jpg?width=500)
Verbatim
e0“statistically significant (P < .05) inhibition of root growth depending on concentration by the extracts when compared with the control groups”
t0“Allium”
Claim · model-written summary
All tested extracts had cytotoxic effects on onion cell division.
- Taxon
- A. cepa
Allium cepae0 - Treatment
- tested extractse0
- Outcome
- cell divisione0
- Direction
- cytotoxic effectse0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“All the tested extracts have been observed to have cytotoxic effects on cell division in A. cepa”
Claim · model-written summary
The extract significantly increased chromosomal aberrations in onion root-tip cells.
- Taxon
- A. cepaAllium cepae0
- Organ / stage
- root tip cellse0
- Treatment
- I. viscosa leaf extracte0
- Outcome
- total number of chromosomal aberrationse0
- Direction
- inducese0
- Comparator
- control groupse0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“I. viscosa leaf extract induces the total number of chromosomal aberrations and micronuclei (MNC) formations in A. cepa root tip cells significantly when compared with control groups”
Claim · model-written summary
The extract significantly increased micronucleus formation in onion root-tip cells.
- Taxon
- A. cepaAllium cepae0
- Organ / stage
- root tip cellse0
- Treatment
- I. viscosa leaf extracte0
- Outcome
- micronuclei (MNC) formationse0
- Direction
- inducese0
- Comparator
- control groupse0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“I. viscosa leaf extract induces the total number of chromosomal aberrations and micronuclei (MNC) formations in A. cepa root tip cells significantly when compared with control groups”
Claim · model-written summary
Extract treatment induced cell death, ghost cells and membrane-damaged cells.
- Treatment
- extract treatmente0
- Outcome
- cell death, ghost cells, cells with membrane damagee0
- Direction
- inductione0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“induction of cell death, ghost cells, cells with membrane damage, and binucleated cells by extract treatment”
t0“Allium”
Claim · model-written summary
Extract treatment induced binucleated cells.
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“induction of cell death, ghost cells, cells with membrane damage, and binucleated cells by extract treatment”
t0“Allium”
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Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.