Abstract
UNLABELLED: CONTEXT. Campomanesia xanthocarpa Berg. (Myrtaceae), popularly known in Brazil as guabiroba, is a plant used as antidiarrheic, anti-inflammatory and antirheumatic agents, and in stomach and hepatic disorders. OBJECTIVE: The antiproliferative and genotoxic effects of aqueous extracts and essential oil of C. xanthocarpa were evaluated. MATERIALS AND METHODS: Cytotoxicity and genotoxicity of the aqueous extracts (6 and 30 mg/mL) and essential oil (0.25%, v/v) obtained from leaves of C. xanthocarpa were evaluated using the Allium cepa L. (Amaryllidaceae) assay. Mitotic index was calculated as the percentage of dividing cells of total cells observed; chromosome abnormalities were observed and counted during cell division. Additionally, the composition of the essential oil and the quantification of the main compounds of the extracts were determined by gas chromatography/mass spectrometry and high performance liquid chromatography coupled with diode array detector, respectively. RESULTS AND DISCUSSION: Aqueous extracts (6 and 30 mg/mL) led to a reduction of 67.7% and 34.1% of the mitotic index, respectively, whereas the treatment with essential oil caused a 48.2% reduction in the mitotic index, when compared with negative control. Chromosomal mutations were observed and included anaphase bridges, delay chromosome, break chromosome, as well as metaphase with disorganized chromosomal and binuclear cells. The main compounds of the essential oil were β-caryophyllene (8.87%), viridiflorol (6.40%), spathulenol (5.16%), δ-cadinene (4.92%), linalool (4.46%) and α-cadinol (4.25%). Gallic acid (3.19%), chlorogenic acid (1.04%), quercetin (2.97%) and rutin (4.82%) were identified in an aqueous extract (30 mg/mL). CONCLUSION: Our results demonstrated that genotoxic and antiproliferative activities are present in C. xanthocarpa infusions using the in vivo onion root-tip cell test.
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Claims 5
Claim · model-written summary
Campomanesia aqueous extract at 6 mg/mL reduced the onion mitotic index by 67.7% versus control.
- Taxon
- Allium cepa
Allium cepat0 - Treatment
- Aqueous extracts (6 and 30 mg/mL)e0
- Outcome
- mitotic indexe0
- Direction
- reductione0
- Value
- 67.7%e0
- Comparator
- negative controle0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Aqueous extracts (6 and 30 mg/mL) led to a reduction of 67.7% and 34.1% of the mitotic index, respectively, whereas the treatment with essential oil caused a 48.2% reduction in the mitotic index, when compared with negative control”
t0“Allium cepa”
Claim · model-written summary
Campomanesia aqueous extract at 30 mg/mL reduced the onion mitotic index by 34.1% versus control.
- Taxon
- Allium cepaAllium cepat0
- Treatment
- Aqueous extracts (6 and 30 mg/mL)e0
- Outcome
- mitotic indexe0
- Direction
- reductione0
- Value
- 34.1%e0
- Comparator
- negative controle0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Aqueous extracts (6 and 30 mg/mL) led to a reduction of 67.7% and 34.1% of the mitotic index, respectively, whereas the treatment with essential oil caused a 48.2% reduction in the mitotic index, when compared with negative control”
t0“Allium cepa”
Claim · model-written summary
Campomanesia essential oil reduced the onion mitotic index by 48.2% versus control.
- Taxon
- Allium cepaAllium cepat0
- Treatment
- essential oile0
- Outcome
- mitotic indexe0
- Direction
- reductione0
- Value
- 48.2%e0
- Comparator
- negative controle0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“the treatment with essential oil caused a 48.2% reduction in the mitotic index, when compared with negative control”
t0“Allium cepa”
Claim · model-written summary
Chromosomal mutations including bridges, delayed and broken chromosomes, disorganized metaphases and binuclear cells were observed in the onion assay.
- Taxon
- Allium cepaAllium cepat0
- Outcome
- Chromosomal mutationse0
- Qualifier
- anaphase bridges, delay chromosome, break chromosome, as well as metaphase with disorganized chromosomal and binuclear cellse0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Chromosomal mutations were observed and included anaphase bridges, delay chromosome, break chromosome, as well as metaphase with disorganized chromosomal and binuclear cells”
t0“Allium cepa”
Claim · model-written summary
The Campomanesia essential oil contained β-caryophyllene at 8.87%.
Verbatim
e0“The main compounds of the essential oil were β-caryophyllene (8.87%)”
e1“The antiproliferative and genotoxic effects of aqueous extracts and essential oil of C. xanthocarpa were evaluated.”
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botanical · cytology · Allium cepa (onion)Positive and negative results
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