Abstract
Interactions between TALE (three-amino acid loop extension) homeodomain proteins play important roles in the development of both fungi and animals. Although in plants, two different subclasses of TALE proteins include important developmental regulators, the existence of interactions between plant TALE proteins has remained unexplored. We have used the yeast two-hybrid system to demonstrate that the Arabidopsis BELL1 (BEL1) homeodomain protein can selectively heterodimerize with specific KNAT homeodomain proteins. Interaction is mediated by BEL1 sequences N terminal to the homeodomain and KNAT sequences including the MEINOX domain. These findings validate the hypothesis that the MEINOX domain has been conserved between plants and animals as an interaction domain for developmental regulators. In yeast, BEL1 and KNAT proteins can activate transcription only as a heterodimeric complex, suggesting a role for such complexes in planta. Finally, overlapping patterns of BEL1 and SHOOT MERISTEMLESS (STM) expression within the inflorescence meristem suggest a role for the BEL1-STM complex in maintaining the indeterminacy of the inflorescence meristem.
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Claims 6
Claim · model-written summary
In the yeast two-hybrid system, Arabidopsis BEL1 can selectively heterodimerize with specific KNAT homeodomain proteins.
- Taxon
- Arabidopsis
Arabidopsist0 - Gene
- Arabidopsis BELL1e0
- Outcome
- selectively heterodimerize with specific KNAT homeodomain proteinse0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“Arabidopsis”
e0“the Arabidopsis BELL1 (BEL1) homeodomain protein can selectively heterodimerize with specific KNAT homeodomain proteins”
Claim · model-written summary
The BEL1-KNAT interaction is mediated by BEL1 sequences N terminal to the homeodomain and KNAT sequences including the MEINOX domain.
- Taxon
- ArabidopsisArabidopsist0
- Gene
- BEL1 sequences N terminal to the homeodomaine0
- Outcome
- Interactione0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“Arabidopsis”
e0“Interaction is mediated by BEL1 sequences N terminal to the homeodomain and KNAT sequences including the MEINOX domain”
Claim · model-written summary
In yeast, BEL1 and KNAT proteins can activate transcription only as a heterodimeric complex.
- Taxon
- ArabidopsisArabidopsist0
- Gene
- BEL1 and KNAT proteinse0
- Outcome
- activate transcription only as a heterodimeric complexe0
- Setting
- yeaste0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“Arabidopsis”
e0“In yeast, BEL1 and KNAT proteins can activate transcription only as a heterodimeric complex”
Claim · model-written summary
BEL1 and SHOOT MERISTEMLESS (STM) expression patterns overlap within the inflorescence meristem.
- Taxon
- ArabidopsisArabidopsist0
- Organ / stage
- inflorescence meristeme0
- Gene
- BEL1e0
- Outcome
- overlapping patterns of BEL1 and SHOOT MERISTEMLESS (STM) expressione0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“Arabidopsis”
e0“overlapping patterns of BEL1 and SHOOT MERISTEMLESS (STM) expression within the inflorescence meristem”
Claim · model-written summary
The authors suggest a role for the BEL1-STM complex in maintaining the indeterminacy of the inflorescence meristem.
- Taxon
- ArabidopsisArabidopsist0
- Gene
- BEL1-STM complexe0
- Outcome
- indeterminacy of the inflorescence meristeme0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“Arabidopsis”
e0“suggest a role for the BEL1-STM complex in maintaining the indeterminacy of the inflorescence meristem”
Claim · model-written summary
The authors interpret the findings as validating that the MEINOX domain has been conserved between plants and animals as an interaction domain for developmental regulators.
- Taxon
- ArabidopsisArabidopsist0
- Gene
- MEINOX domaine0
- Outcome
- conserved between plants and animals as an interaction domaine0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“Arabidopsis”
e0“the MEINOX domain has been conserved between plants and animals as an interaction domain for developmental regulators”