Abstract
Cryptochromes are widely distributed blue light photoreceptors involved in numerous signaling functions in plants and animals. Both plant and animal-type cryptochromes are found to bind ATP and display intrinsic autokinase activity; however the functional significance of this activity remains a matter of speculation. Here we show in purified preparations of Arabidopsis cry1 that ATP binding induces conformational change independently of light and increases the amount and stability of light-induced flavin radical formation. Nucleotide binding may thereby provide a mechanism whereby light responsivity in organisms can be regulated through modulation of cryptochrome photoreceptor conformation.
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Claims 2
Claim · model-written summary
ATP binding induces a conformational change in Arabidopsis cry1 independently of light.
- Taxon
- Arabidopsis
Arabidopsist0 - Treatment
- ATP bindinge1
- Gene
- Arabidopsis cry1e3
- Outcome
- conformational changee1
- Qualifier
- independently of lighte1
Not reportedComparatorDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“Arabidopsis cryptochrome”
e1“ATP binding induces conformational change independently of light”
e3“purified preparations of Arabidopsis cry1”
Claim · model-written summary
ATP binding increases the amount and stability of light-induced flavin radical formation in Arabidopsis cry1.
- Taxon
- ArabidopsisArabidopsist0
- Treatment
- ATP bindinge1
- Outcome
- amount and stability of light-induced flavin radical formatione2
- Direction
- increasese2
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“Arabidopsis cryptochrome”
e1“ATP binding induces conformational change independently of light”
e2“increases the amount and stability of light-induced flavin radical formation”
The same questions in other papers
ATP · molecular: metabolites · ArabidopsisPositive and negative results
3 papers in the same direction as this paper · 1 in the opposite direction
- positive
- no effect
- positive
1 paper more in this group
See all 5 papers →Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.