Abstract
Rice inflorescence meristem (IM) activity is essential for panicle development and grain production. How chromatin and epigenetic mechanisms regulate IM activity remains unclear. Genome-wide analysis revealed that in addition to genes involved in the vegetative to reproductive transition, many metabolic and protein synthetic genes were activated in IM compared with shoot apical meristem and that a change in the H3K27me3/H3K4me3 ratio was an important factor for the differential expression of many genes. Thousands of genes gained or lost H3K27me3 in IM, and downregulation of the H3K27 methyltransferase gene SET DOMAIN GROUP 711 (SDG711) or mutation of the H3K4 demethylase gene JMJ703 eliminated the increase of H3K27me3 in many genes. SDG711-mediated H3K27me3 repressed several important genes involved in IM activity and many genes that are silent in the IM but activated during floral organogenesis or other developmental stages. SDG711 overexpression augmented IM activity and increased panicle size; suppression of SDG711 by RNA interference had the opposite effect. Double knockdown/knockout of SDG711 and JMJ703 further reduced panicle size. These results suggest that SDG711 and JMJ703 have agonistic functions in reprogramming the H3K27me3/H3K4me3 ratio and modulating gene expression in the IM.
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Claims 11
Claim · model-written summary
Metabolic and protein-synthesis genes were activated in the inflorescence meristem versus shoot apex.
- Taxon
- Rice
Oryza sativat0 - Organ / stage
- IMe0
- Outcome
- metabolic and protein synthetic genese0
- Direction
- activatede0
- Comparator
- shoot apical meristeme0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“many metabolic and protein synthetic genes were activated in IM compared with shoot apical meristem”
t0“Rice”
Claim · model-written summary
Changes in H3K27me3/H3K4me3 ratio were implicated in differential gene expression.
- Taxon
- RiceOryza sativat0
- Gene
- H3K27me3/H3K4me3e0
- Outcome
- differential expression of many genese0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“a change in the H3K27me3/H3K4me3 ratio was an important factor for the differential expression of many genes.”
t0“Rice”
Claim · model-written summary
Thousands of genes gained or lost H3K27me3 in the inflorescence meristem.
- Taxon
- RiceOryza sativat0
- Organ / stage
- IMe0
- Gene
- H3K27me3e0
- Outcome
- genes gained or lost H3K27me3e0
- Value
- Thousands of genese0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Thousands of genes gained or lost H3K27me3 in IM”
t0“Rice”
Claim · model-written summary
downregulation of SET DOMAIN GROUP 711 (SDG711) eliminated H3K27me3 gains in many genes.
- Taxon
- RiceOryza sativat0
- Treatment
- downregulatione0
- Gene
- SET DOMAIN GROUP 711 (SDG711)e0
- Outcome
- increase of H3K27me3e0
- Direction
- eliminatede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“downregulation of the H3K27 methyltransferase gene SET DOMAIN GROUP 711 (SDG711) or mutation of the H3K4 demethylase gene JMJ703 eliminated the increase of H3K27me3 in many genes.”
t0“Rice”
Claim · model-written summary
mutation of JMJ703 eliminated H3K27me3 gains in many genes.
- Taxon
- RiceOryza sativat0
- Treatment
- mutatione0
- Gene
- JMJ703e0
- Outcome
- increase of H3K27me3e0
- Direction
- eliminatede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“downregulation of the H3K27 methyltransferase gene SET DOMAIN GROUP 711 (SDG711) or mutation of the H3K4 demethylase gene JMJ703 eliminated the increase of H3K27me3 in many genes.”
t0“Rice”
Claim · model-written summary
SDG711-mediated H3K27me3 repressed genes involved in inflorescence-meristem activity.
- Taxon
- RiceOryza sativat0
- Organ / stage
- IMe0
- Gene
- SDG711e0
- Outcome
- genes involved in IM activitye0
- Direction
- repressede0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“SDG711-mediated H3K27me3 repressed several important genes involved in IM activity and many genes that are silent in the IM but activated during floral organogenesis or other developmental stages.”
t0“Rice”
Claim · model-written summary
SDG711-mediated H3K27me3 repressed genes later activated during floral organogenesis.
- Taxon
- RiceOryza sativat0
- Gene
- SDG711e0
- Outcome
- genes that are silent in the IM but activated during floral organogenesise0
- Direction
- repressede0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“SDG711-mediated H3K27me3 repressed several important genes involved in IM activity and many genes that are silent in the IM but activated during floral organogenesis or other developmental stages.”
t0“Rice”
Claim · model-written summary
SDG711 overexpression increased IM activity.
- Taxon
- RiceOryza sativat0
- Treatment
- SDG711 overexpressione0
- Gene
- SDG711e0
- Outcome
- IM activitye0
- Direction
- augmentede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“SDG711 overexpression augmented IM activity and increased panicle size; suppression of SDG711 by RNA interference had the opposite effect.”
t0“Rice”
Claim · model-written summary
SDG711 overexpression increased panicle size.
- Taxon
- RiceOryza sativat0
- Treatment
- SDG711 overexpressione0
- Gene
- SDG711e0
- Outcome
- panicle sizee0
- Direction
- increasede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“SDG711 overexpression augmented IM activity and increased panicle size; suppression of SDG711 by RNA interference had the opposite effect.”
t0“Rice”
Claim · model-written summary
RNA interference suppression of SDG711 had the opposite effect on inflorescence-meristem activity and panicle size.
- Taxon
- RiceOryza sativat0
- Treatment
- suppression of SDG711 by RNA interferencee0
- Gene
- SDG711e0
- Outcome
- opposite effecte0
- Direction
- opposite effecte0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“SDG711 overexpression augmented IM activity and increased panicle size; suppression of SDG711 by RNA interference had the opposite effect.”
t0“Rice”
Claim · model-written summary
Combined SDG711 and JMJ703 loss further reduced panicle size.
- Taxon
- RiceOryza sativat0
- Treatment
- Double knockdown/knockoute0
- Gene
- SDG711 and JMJ703e0
- Outcome
- panicle sizee0
- Direction
- further reducede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Double knockdown/knockout of SDG711 and JMJ703 further reduced panicle size.”
t0“Rice”
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