Abstract
In addition to six known flavonoids quercitrin, hyperoside, avicularin, rutin, quercetin and kaemferol, a new flavonol glycoside named 6 -O-acetyl quercetin 3-O-#beta#-D-alloside (1) was isolated from the aerial parts of Hypericum perforatum L. The structures were determined on the basis of spectroscopic methods (UV, IR, FAB-MS, ~(1)H-NMR and ~(13)C-NMR). Antifungal assay of all componds showed that metabolite 1, quercitrin and quercetin were inhibitory to the growth of phytopathogenic fungus Helminthosporium sativum Pamel King et Bakke with minimum inhibitory concentrations (MICs) of 25, 50 and 50#mu#g/mL, respectively. Moreover, glycoside 1 and quercitrin were also shown to be able to inhibit the growth of Fusarium graminearum Schw. with MIC of 100 #mu#g/mL. The MICs of ketoconazole used as control against the test fungi were 0.5#mu#g/mL in our assay.
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Claims 9
Claim · model-written summary
A new flavonol glycoside was isolated from Hypericum perforatum aerial parts.
- Taxon
- Hypericum perforatum L.
_Hypericum_perforatum_flower_and_buttons.jpg?width=60)
Hypericum perforatume0 - Organ / stage
- aerial partse0
- Outcome
- 6 -O-acetyl quercetin 3-O-#beta#-D-alloside (1)e0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
_Hypericum_perforatum_flower_and_buttons.jpg?width=500)
Verbatim
e0“a new flavonol glycoside named 6 -O-acetyl quercetin 3-O-#beta#-D-alloside (1) was isolated from the aerial parts of Hypericum perforatum L.”
Claim · model-written summary
Quercitrin, hyperoside and avicularin were identified among known Hypericum flavonoids.
- Taxon
- Hypericum perforatum L.Hypericum perforatume1
- Outcome
- quercitrin, hyperoside, avicularine0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“six known flavonoids quercitrin, hyperoside, avicularin, rutin, quercetin and kaemferol”
e1“Hypericum perforatum L.”
Claim · model-written summary
Rutin, quercetin and kaemferol were identified among known Hypericum flavonoids.
- Taxon
- Hypericum perforatum L.Hypericum perforatume1
- Outcome
- rutin, quercetin and kaemferole0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“six known flavonoids quercitrin, hyperoside, avicularin, rutin, quercetin and kaemferol”
e1“Hypericum perforatum L.”
Claim · model-written summary
The new glycoside inhibited Helminthosporium sativum growth with MIC 25 #mu#g/mL.
Verbatim
e0“metabolite 1, quercitrin and quercetin were inhibitory to the growth of phytopathogenic fungus Helminthosporium sativum Pamel King et Bakke with minimum inhibitory concentrations (MICs) of 25, 50 and 50#mu#g/mL, respectively.”
e1“6 -O-acetyl quercetin 3-O-#beta#-D-alloside (1)”
Claim · model-written summary
Quercitrin inhibited Helminthosporium sativum growth with MIC 50 #mu#g/mL.
Verbatim
e0“metabolite 1, quercitrin and quercetin were inhibitory to the growth of phytopathogenic fungus Helminthosporium sativum Pamel King et Bakke with minimum inhibitory concentrations (MICs) of 25, 50 and 50#mu#g/mL, respectively.”
Claim · model-written summary
Quercetin inhibited Helminthosporium sativum growth with MIC 50#mu#g/mL.
Verbatim
e0“metabolite 1, quercitrin and quercetin were inhibitory to the growth of phytopathogenic fungus Helminthosporium sativum Pamel King et Bakke with minimum inhibitory concentrations (MICs) of 25, 50 and 50#mu#g/mL, respectively.”
Claim · model-written summary
Glycoside 1 inhibited Fusarium graminearum growth with MIC 100 #mu#g/mL.
- Taxon
- Fusarium graminearum Schw.
_on_Corn_(Zea_mays)_at_Waimea%2C_Hawaii.jpg?width=60)
Fusarium graminearume0 - Treatment
- glycoside 1e0
- Outcome
- growth of Fusarium graminearum Schw.e0
- Direction
- inhibite0
- Value
- 100 #mu#g/mLe0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
_on_Corn_(Zea_mays)_at_Waimea%2C_Hawaii.jpg?width=500)
Verbatim
e0“glycoside 1 and quercitrin were also shown to be able to inhibit the growth of Fusarium graminearum Schw. with MIC of 100 #mu#g/mL.”
Claim · model-written summary
Quercitrin inhibited Fusarium graminearum growth with MIC 100 #mu#g/mL.
- Taxon
- Fusarium graminearum Schw.Fusarium graminearume0
- Treatment
- quercitrine0
- Outcome
- growth of Fusarium graminearum Schw.e0
- Direction
- inhibite0
- Value
- 100 #mu#g/mLe0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“glycoside 1 and quercitrin were also shown to be able to inhibit the growth of Fusarium graminearum Schw. with MIC of 100 #mu#g/mL.”
Claim · model-written summary
Ketoconazole control MIC against test fungi was 0.5#mu#g/mL.
Not reportedTaxon
Verbatim
e0“The MICs of ketoconazole used as control against the test fungi were 0.5#mu#g/mL in our assay.”