Abstract
An aqueous ethanolic extract of the stem bark of Garcinia buchananii showed strong antioxidative activity using H2O2 scavenging, oxygen radical absorbance capacity (ORAC), and Trolox equivalent antioxidant capacity (TEAC) assays. Activity-guided fractionation afforded three new compounds, isomanniflavanone (1), an ent-eriodictyol-(3α→6)-dihydroquercetin-linked biflavanone, 1,5-dimethoxyajacareubin (2), and the depsidone garcinisidone-G (3), and six known compounds, (2″R,3″R)-preussianon, euxanthone, 2-isoprenyl-1,3,5,6-tetrahydroxyxanthone, jacareubin, isogarcinol, and garcinol. All compounds were described for the first time in Garcinia buchananii. The absolute configurations were determined by a combination of NMR, ECD spectroscopy, and polarimetry. These natural products showed high in vitro antioxidative power, especially isomanniflavanone, with an EC50 value of 8.5 μM (H2O2 scavenging), 3.50/4.95 mmol TE/mmol (H/L-TEAC), and 7.54/14.56 mmol TE/mmol (H/L-ORAC).
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Claims 10
Claim · model-written summary
The stem-bark extract showed strong antioxidant activity in three assays.
- Taxon
- Garcinia buchananiiGarcinia buchananiie0
- Organ / stage
- stem barke0
- Outcome
- antioxidative activitye0
- Qualifier
- stronge0
Verbatim
e0“An aqueous ethanolic extract of the stem bark of Garcinia buchananii showed strong antioxidative activity using H2O2 scavenging, oxygen radical absorbance capacity (ORAC), and Trolox equivalent antioxidant capacity (TEAC) assays.”
Claim · model-written summary
Fractionation yielded three new compounds: isomanniflavanone, 1,5-dimethoxyajacareubin, and garcinisidone-G.
- Taxon
- Garcinia buchananiiGarcinia buchananiit0
- Outcome
- three new compoundse0
- Qualifier
- isomanniflavanone (1), an ent-eriodictyol-(3α→6)-dihydroquercetin-linked biflavanone, 1,5-dimethoxyajacareubin (2), and the depsidone garcinisidone-G (3)e0
Verbatim
e0“Activity-guided fractionation afforded three new compounds, isomanniflavanone (1), an ent-eriodictyol-(3α→6)-dihydroquercetin-linked biflavanone, 1,5-dimethoxyajacareubin (2), and the depsidone garcinisidone-G (3)”
t0“Garcinia buchananii”
Claim · model-written summary
Preussianon, euxanthone, and 2-isoprenyl-1,3,5,6-tetrahydroxyxanthone were isolated.
- Taxon
- Garcinia buchananiiGarcinia buchananiit0
- Outcome
- (2″R,3″R)-preussianon, euxanthone, 2-isoprenyl-1,3,5,6-tetrahydroxyxanthonee0
Verbatim
e0“six known compounds, (2″R,3″R)-preussianon, euxanthone, 2-isoprenyl-1,3,5,6-tetrahydroxyxanthone, jacareubin, isogarcinol, and garcinol.”
t0“Garcinia buchananii”
Claim · model-written summary
Jacareubin, isogarcinol, and garcinol were isolated.
- Taxon
- Garcinia buchananiiGarcinia buchananiit0
- Outcome
- jacareubin, isogarcinol, and garcinole0
Verbatim
e0“six known compounds, (2″R,3″R)-preussianon, euxanthone, 2-isoprenyl-1,3,5,6-tetrahydroxyxanthone, jacareubin, isogarcinol, and garcinol.”
t0“Garcinia buchananii”
Claim · model-written summary
All compounds were reported for the first time in Garcinia buchananii.
- Taxon
- Garcinia buchananiiGarcinia buchananiie0
- Outcome
- All compoundse0
- Qualifier
- for the first timee0
Verbatim
e0“All compounds were described for the first time in Garcinia buchananii.”
Claim · model-written summary
Absolute configurations were determined through NMR, ECD spectroscopy, and polarimetry.
- Taxon
- Garcinia buchananiiGarcinia buchananiit0
- Outcome
- absolute configurationse0
Verbatim
e0“The absolute configurations were determined by a combination of NMR, ECD spectroscopy, and polarimetry.”
t0“Garcinia buchananii”
Claim · model-written summary
The natural products showed high in vitro antioxidant power, especially isomanniflavanone.
- Taxon
- Garcinia buchananiiGarcinia buchananiit0
- Outcome
- in vitro antioxidative powere0
- Qualifier
- especially isomanniflavanonee0
Verbatim
e0“These natural products showed high in vitro antioxidative power, especially isomanniflavanone”
t0“Garcinia buchananii”
Claim · model-written summary
Isomanniflavanone had an H2O2 scavenging EC50 of 8.5 μM.
- Taxon
- Garcinia buchananiiGarcinia buchananiit0
- Outcome
- EC50e0
- Value
- 8.5 μMe0
- Qualifier
- H2O2 scavenginge0
Verbatim
e0“especially isomanniflavanone, with an EC50 value of 8.5 μM (H2O2 scavenging), 3.50/4.95 mmol TE/mmol (H/L-TEAC), and 7.54/14.56 mmol TE/mmol (H/L-ORAC).”
t0“Garcinia buchananii”
Claim · model-written summary
Isomanniflavanone had H/L-TEAC values of 3.50/4.95 mmol TE/mmol.
- Taxon
- Garcinia buchananiiGarcinia buchananiit0
- Outcome
- H/L-TEACe0
- Value
- 3.50/4.95 mmol TE/mmole0
Verbatim
e0“especially isomanniflavanone, with an EC50 value of 8.5 μM (H2O2 scavenging), 3.50/4.95 mmol TE/mmol (H/L-TEAC), and 7.54/14.56 mmol TE/mmol (H/L-ORAC).”
t0“Garcinia buchananii”
Claim · model-written summary
Isomanniflavanone had H/L-ORAC values of 7.54/14.56 mmol TE/mmol.
- Taxon
- Garcinia buchananiiGarcinia buchananiit0
- Outcome
- H/L-ORACe0
- Value
- 7.54/14.56 mmol TE/mmole0
Verbatim
e0“especially isomanniflavanone, with an EC50 value of 8.5 μM (H2O2 scavenging), 3.50/4.95 mmol TE/mmol (H/L-TEAC), and 7.54/14.56 mmol TE/mmol (H/L-ORAC).”
t0“Garcinia buchananii”