Abstract
Stauntonia hexaphylla (Lardizabalaceae) is an important medicinal plant in Korea, Japan, and China. Its leaves are used to treat many diseases because of their analgesic, sedative, and diuretic effects; however, there are few reports on their chemical constituents and biological activities. This study divided an ethanol extract into dichloromethane (DCM), ethyl acetate (EtOAc), and water fractions. Bioassay-guided fractionation of the ethanol extracts led to the isolation of seven compounds (1–7). To our knowledge, this is the first report of 1–7 from S. hexaphylla. The anti-inflammatory effects were investigated by suppressing cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in Western blots. The ethanol extract (20 µg/mL), DCM fraction (20 µg/mL), and compound 1 (10 µM) decreased COX-2 and iNOS expression significantly in LPS-induced RAW264.7 cells. These results suggest that S. hexaphylla leaves and compound 1 are useful candidates for treating inflammatory and other diseases.
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Claims 5
Claim · model-written summary
Bioassay-guided fractionation of S. hexaphylla leaf ethanol extract yielded seven compounds, first reported from this species.
- Taxon
- Stauntonia hexaphylla
Stauntonia hexaphyllae0 - Outcome
- seven compoundse1
- Qualifier
- first report of 1–7 from S. hexaphyllae2
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Stauntonia hexaphylla (Lardizabalaceae) is an important medicinal plant”
e1“led to the isolation of seven compounds (1–7)”
e2“To our knowledge, this is the first report of 1–7 from S. hexaphylla”
Claim · model-written summary
The ethanol extract (20 µg/mL) significantly decreased COX-2 and iNOS expression in LPS-induced RAW264.7 cells.
- Taxon
- Stauntonia hexaphyllaStauntonia hexaphyllae0
- Treatment
- ethanol extract (20 µg/mL)e1
- Outcome
- COX-2 and iNOS expressione1
- Direction
- decreasede1
- Qualifier
- LPS-induced RAW264.7 cellse1
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Stauntonia hexaphylla (Lardizabalaceae) is an important medicinal plant”
e1“The ethanol extract (20 µg/mL), DCM fraction (20 µg/mL), and compound 1 (10 µM) decreased COX-2 and iNOS expression significantly in LPS-induced RAW264.7 cells”
Claim · model-written summary
The DCM fraction (20 µg/mL) significantly decreased COX-2 and iNOS expression in LPS-induced RAW264.7 cells.
- Taxon
- Stauntonia hexaphyllaStauntonia hexaphyllae0
- Treatment
- DCM fraction (20 µg/mL)e1
- Outcome
- COX-2 and iNOS expressione1
- Direction
- decreasede1
- Qualifier
- LPS-induced RAW264.7 cellse1
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Stauntonia hexaphylla (Lardizabalaceae) is an important medicinal plant”
e1“The ethanol extract (20 µg/mL), DCM fraction (20 µg/mL), and compound 1 (10 µM) decreased COX-2 and iNOS expression significantly in LPS-induced RAW264.7 cells”
Claim · model-written summary
Compound 1 (10 µM) significantly decreased COX-2 and iNOS expression in LPS-induced RAW264.7 cells.
- Taxon
- Stauntonia hexaphyllaStauntonia hexaphyllae0
- Treatment
- compound 1 (10 µM)e1
- Outcome
- COX-2 and iNOS expressione1
- Direction
- decreasede1
- Qualifier
- LPS-induced RAW264.7 cellse1
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Stauntonia hexaphylla (Lardizabalaceae) is an important medicinal plant”
e1“The ethanol extract (20 µg/mL), DCM fraction (20 µg/mL), and compound 1 (10 µM) decreased COX-2 and iNOS expression significantly in LPS-induced RAW264.7 cells”
Claim · model-written summary
S. hexaphylla leaves and compound 1 are useful candidates for treating inflammatory and other diseases.
- Taxon
- S. hexaphyllaStauntonia hexaphyllae1
- Outcome
- useful candidates for treating inflammatory and other diseasese1
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“These results suggest that S. hexaphylla leaves and compound 1 are useful candidates for treating inflammatory and other diseases”