Abstract
Lomatogonium rotatum (L.) Fries ex Nym (L. rotatum), a member of Gentianaceae, is an important mongolian medicine in China used to treat febrile diseases in liver and gallbladder. The aim of present study was to investigate the chemical constituents and metabolites of the 50% ethanol fraction of L. rotatum (50EtLR). Firstly, the extract of L. rotatum was partitioned by macroporous resin to obtain the target fraction (50EtLR), then several compounds were isolated from 50EtLR to obtained the standards for further analysis of chemical constituents of 50EtLR. Secondly, the chemical constituents of 50EtLR were characterized using the ultra-high performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (UHPLC-Q-TOF-MS/MS). Finally, prototype constituents and related metabolites were analyzed after orally administerng 50EtLR to rats. As a result, a new compound, 6-O-[β-d-xylopyranosyl-(1 → 6)-O-β-d-glucopyranosyl]-1,4,8-trimethoxyxanthone (6) along with seven known compounds (1-5, 7 and 8) were isolated from the 50EtLR, 92 components were either unambiguously or tentatively identified. Additionally, 34 prototype constituents and 112 metabolites in rat plasma along with 32 prototype constituents and 53 metabolites in rat liver were tentatively identified. Therefore, xanthones and flavonoids were the main chemical constituents of 50EtLR and sulfation and glucuronidation are the main enzyme-induced metabolic pathways involved post-administration.
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Claims 9
Claim · model-written summary
Chemical fingerprinting identified 92 components of the 50% ethanol fraction of Lomatogonium rotatum.
- Taxon
- Lomatogonium rotatum
Lomatogonium rotatume1 - Outcome
- componentse3
- Value
- 92e3
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“Lomatogonium rotatum (L.) Fries ex Nym (L. rotatum), a member of Gentianaceae, is an important mongolian medicine in China used to treat febrile diseases in liver and gallbladder”
e3“92 components were either unambiguously or tentatively identified”
Claim · model-written summary
Seven known compounds were isolated from the 50% ethanol fraction of Lomatogonium rotatum.
- Taxon
- Lomatogonium rotatumLomatogonium rotatume1
- Outcome
- seven known compoundse2
- Value
- sevene2
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“Lomatogonium rotatum (L.) Fries ex Nym (L. rotatum), a member of Gentianaceae, is an important mongolian medicine in China used to treat febrile diseases in liver and gallbladder”
e2“along with seven known compounds (1-5, 7 and 8) were isolated from the 50EtLR”
Claim · model-written summary
A new xanthone compound was isolated from the 50% ethanol fraction of Lomatogonium rotatum.
- Taxon
- Lomatogonium rotatumLomatogonium rotatume1
- Outcome
- a new compounde3
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“Lomatogonium rotatum (L.) Fries ex Nym (L. rotatum), a member of Gentianaceae, is an important mongolian medicine in China used to treat febrile diseases in liver and gallbladder”
e3“As a result, a new compound”
Claim · model-written summary
Xanthones and flavonoids were the main chemical constituents of the 50% ethanol fraction.
- Taxon
- Lomatogonium rotatumLomatogonium rotatume1
- Outcome
- main chemical constituentse6
- Qualifier
- xanthones and flavonoidse6
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“Lomatogonium rotatum (L.) Fries ex Nym (L. rotatum), a member of Gentianaceae, is an important mongolian medicine in China used to treat febrile diseases in liver and gallbladder”
e6“Therefore, xanthones and flavonoids were the main chemical constituents of 50EtLR”
Claim · model-written summary
Sulfation and glucuronidation are the main enzyme-induced metabolic pathways after administration.
- Taxon
- Lomatogonium rotatumLomatogonium rotatume1
- Outcome
- main enzyme-induced metabolic pathwayse7
- Qualifier
- sulfation and glucuronidatione7
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“Lomatogonium rotatum (L.) Fries ex Nym (L. rotatum), a member of Gentianaceae, is an important mongolian medicine in China used to treat febrile diseases in liver and gallbladder”
e7“sulfation and glucuronidation are the main enzyme-induced metabolic pathways involved post-administration”
Claim · model-written summary
34 prototype constituents were identified in rat plasma after oral administration of the fraction.
- Taxon
- Lomatogonium rotatumLomatogonium rotatume1
- Organ / stage
- rat plasmae4
- Outcome
- prototype constituentse4
- Value
- 34e4
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“Lomatogonium rotatum (L.) Fries ex Nym (L. rotatum), a member of Gentianaceae, is an important mongolian medicine in China used to treat febrile diseases in liver and gallbladder”
e4“34 prototype constituents and 112 metabolites in rat plasma”
Claim · model-written summary
112 metabolites were identified in rat plasma after oral administration of the fraction.
- Taxon
- Lomatogonium rotatumLomatogonium rotatume1
- Organ / stage
- rat plasmae4
- Outcome
- metabolitese4
- Value
- 112e4
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“Lomatogonium rotatum (L.) Fries ex Nym (L. rotatum), a member of Gentianaceae, is an important mongolian medicine in China used to treat febrile diseases in liver and gallbladder”
e4“34 prototype constituents and 112 metabolites in rat plasma”
Claim · model-written summary
32 prototype constituents were identified in rat liver after oral administration of the fraction.
- Taxon
- Lomatogonium rotatumLomatogonium rotatume1
- Organ / stage
- rat livere5
- Outcome
- prototype constituentse5
- Value
- 32e5
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“Lomatogonium rotatum (L.) Fries ex Nym (L. rotatum), a member of Gentianaceae, is an important mongolian medicine in China used to treat febrile diseases in liver and gallbladder”
e5“32 prototype constituents and 53 metabolites in rat liver”
Claim · model-written summary
53 metabolites were identified in rat liver after oral administration of the fraction.
- Taxon
- Lomatogonium rotatumLomatogonium rotatume1
- Organ / stage
- rat livere5
- Outcome
- metabolitese5
- Value
- 53e5
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e1“Lomatogonium rotatum (L.) Fries ex Nym (L. rotatum), a member of Gentianaceae, is an important mongolian medicine in China used to treat febrile diseases in liver and gallbladder”
e5“32 prototype constituents and 53 metabolites in rat liver”