Abstract
In Arabidopsis, a zygote undergoes asymmetrical cell division that establishes the first two distinct cell types of early proembryos, apical and basal cells. However, the genome-wide transcriptional activities that guide divergence of apical and basal cell development remain unknown. Here, we present a comprehensive transcriptome analysis of apical and basal cell lineages, uncovering distinct molecular pathways during cell lineage specification. Selective deletion of inherited transcripts and specific de novo transcription contribute to the establishment of cell lineage-specific pathways for cell fate specification. Embryo-related pathways have been specifically activated in apical cell lineage since 1-cell embryo stage, but quick transcriptome remodeling toward suspensor-specific pathways are found in basal cell lineage. Furthermore, long noncoding RNAs and alternative splicing isoforms may be involved in cell lineage specification. This work also provides a valuable lineage-specific transcriptome resource to elucidate the molecular pathways for divergence of apical and basal cell lineages at genome-wide scale.
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Claims 8
Claim · model-written summary
Apical and basal cell lineages have distinct molecular pathways during specification.
- Taxon
- Arabidopsis
Arabidopsise0 - Organ / stage
- cell lineagee1
- Outcome
- distinct molecular pathwayse1
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“In Arabidopsis, a zygote undergoes asymmetrical cell division”
e1“uncovering distinct molecular pathways during cell lineage specification.”
Claim · model-written summary
Selective deletion of inherited transcripts contributes to lineage-specific pathways for cell fate specification.
- Taxon
- ArabidopsisArabidopsise0
- Outcome
- cell lineage-specific pathways for cell fate specificatione1
- Qualifier
- Selective deletion of inherited transcriptse1
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“In Arabidopsis, a zygote”
e1“Selective deletion of inherited transcripts and specific de novo transcription contribute to the establishment of cell lineage-specific pathways for cell fate specification.”
Claim · model-written summary
Specific de novo transcription contributes to lineage-specific pathways for cell fate specification.
- Taxon
- ArabidopsisArabidopsise0
- Outcome
- cell lineage-specific pathways for cell fate specificatione1
- Qualifier
- specific de novo transcriptione1
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“In Arabidopsis, a zygote”
e1“Selective deletion of inherited transcripts and specific de novo transcription contribute to the establishment of cell lineage-specific pathways for cell fate specification.”
Claim · model-written summary
Embryo-related pathways were specifically activated in the apical lineage from the 1-cell embryo stage.
- Taxon
- ArabidopsisArabidopsise0
- Organ / stage
- apical cell lineagee1
- Outcome
- Embryo-related pathwayse1
- Direction
- activatede1
- Qualifier
- since 1-cell embryo stagee1
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“In Arabidopsis, a zygote”
e1“Embryo-related pathways have been specifically activated in apical cell lineage since 1-cell embryo stage”
Claim · model-written summary
The basal lineage showed rapid transcriptome remodeling toward suspensor-specific pathways.
- Taxon
- ArabidopsisArabidopsise0
- Organ / stage
- basal cell lineagee1
- Outcome
- quick transcriptome remodeling toward suspensor-specific pathwayse1
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“In Arabidopsis, a zygote”
e1“quick transcriptome remodeling toward suspensor-specific pathways are found in basal cell lineage.”
Claim · model-written summary
Long noncoding RNAs may participate in cell lineage specification.
- Taxon
- ArabidopsisArabidopsise0
- Gene
- long noncoding RNAse1
- Outcome
- cell lineage specificatione1
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“In Arabidopsis, a zygote”
e1“long noncoding RNAs and alternative splicing isoforms may be involved in cell lineage specification.”
Claim · model-written summary
Alternative splicing isoforms may participate in cell lineage specification.
- Taxon
- ArabidopsisArabidopsise0
- Gene
- alternative splicing isoformse1
- Outcome
- cell lineage specificatione1
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“In Arabidopsis, a zygote”
e1“long noncoding RNAs and alternative splicing isoforms may be involved in cell lineage specification.”
Claim · model-written summary
The study provides a lineage-specific transcriptome resource for apical and basal lineages.
- Taxon
- ArabidopsisArabidopsise0
- Outcome
- lineage-specific transcriptome resourcee1
- Value
- genome-wide scalee1
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“In Arabidopsis, a zygote”
e1“This work also provides a valuable lineage-specific transcriptome resource to elucidate the molecular pathways for divergence of apical and basal cell lineages at genome-wide scale.”