Abstract
The discovery of new antibiotics to overcome the growing resistance problem as well as the discovery of new natural, safe antioxidants to combat oxidative stress are still urgently needed. Medicinal plants are known to produce potential therapeutic substances which are more biologically selective than synthetic compounds. Therefore, we explored the bioactivities of 35 ethanolic extracts from 24 underexplored plant species collected in Halmahera, to find potential sources for antibacterial and antioxidant agents. Dried plant parts were extracted using ethanol 96%. Thin layer chromatography-direct-bioautography (TLC-DB) and minimum inhibitory concentration (MIC) determination were used to evaluate the antibacterial effect. Antioxidant activity was determined against DPPH using TLC-DB and microdilution assay. Total phenolic content (TPC) was determined using Folin-Ciocalteu’s method. The ethanolic extracts exhibited moderate to weak antibacterial activity against Escherichia coli and Staphylococcus aureus. However, the leaf extract of Elaeocarpus dolichostylus, Elaeocarpus multiflorus, and Psychotria celebica as well as the stem bark extract of Elaeocarpus dolichostylus, Cinnamomum sintoc, and Garcinia latissima displayed very strong antioxidant activities against DPPH with AAI values between 4.60 to 13.42. A strong correlation between TPC and antioxidant activity with r = 0.8712 was observed. Despite the moderate to weak antibacterial activity, eight underexplored plant species exhibit strong antioxidant activities. A high correlation between TPC and antioxidant activity indicating a prominent role of phenolic compounds in the plants’ antioxidant properties. These findings indicate that collected plants from Halmahera are potential to be studied and developed further as the potential sources for novel antioxidants.
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Claims 7
Claim · model-written summary
Ethanolic extracts of underexplored plant species show moderate to weak antibacterial activity against Escherichia coli and Staphylococcus aureus.
Verbatim
t0“A bioprospection study of underexplored plant species”
e1“The ethanolic extracts exhibited moderate to weak antibacterial activity against Escherichia coli and Staphylococcus aureus”
Claim · model-written summary
Leaf extracts of Elaeocarpus dolichostylus, Elaeocarpus multiflorus and Psychotria celebica showed very strong DPPH antioxidant activity, AAI 4.60 to 13.42.
- Taxon
- Elaeocarpus dolichostylus, Elaeocarpus multiflorus, and Psychotria celebica
Elaeocarpus multiflorusElaeocarpus dolichostylusPsychotria celebicae2 - Organ / stage
- leaf extracte2
- Outcome
- antioxidant activities against DPPHe2
- Value
- AAI values between 4.60 to 13.42e2
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e2“the leaf extract of Elaeocarpus dolichostylus, Elaeocarpus multiflorus, and Psychotria celebica as well as the stem bark extract of Elaeocarpus dolichostylus, Cinnamomum sintoc, and Garcinia latissima displayed very strong antioxidant activities against DPPH with AAI values between 4.60 to 13.42”
Claim · model-written summary
Stem bark extracts of Elaeocarpus dolichostylus, Cinnamomum sintoc and Garcinia latissima showed very strong DPPH antioxidant activity, AAI 4.60 to 13.42.
- Taxon
- Elaeocarpus dolichostylus, Cinnamomum sintoc, and Garcinia latissimaGarcinia latissima
Cinnamomum sintocElaeocarpus dolichostyluse2 - Organ / stage
- stem bark extracte2
- Outcome
- antioxidant activities against DPPHe2
- Value
- AAI values between 4.60 to 13.42e2
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e2“the leaf extract of Elaeocarpus dolichostylus, Elaeocarpus multiflorus, and Psychotria celebica as well as the stem bark extract of Elaeocarpus dolichostylus, Cinnamomum sintoc, and Garcinia latissima displayed very strong antioxidant activities against DPPH with AAI values between 4.60 to 13.42”
Claim · model-written summary
Total phenolic content and antioxidant activity are strongly correlated across the extracts (r = 0.8712), with antioxidant activity increasing with TPC.
Verbatim
t0“A bioprospection study of underexplored plant species”
e3“A strong correlation between TPC and antioxidant activity with r = 0.8712 was observed”
Claim · model-written summary
Phenolic compounds are a prominent factor in the antioxidant properties of the studied plants.
Verbatim
t0“A bioprospection study of underexplored plant species”
e4“A high correlation between TPC and antioxidant activity indicating a prominent role of phenolic compounds in the plants’ antioxidant properties”
Claim · model-written summary
Eight underexplored plant species exhibit strong antioxidant activities.
Verbatim
t0“A bioprospection study of underexplored plant species”
e5“Despite the moderate to weak antibacterial activity, eight underexplored plant species exhibit strong antioxidant activities”
Claim · model-written summary
Plants collected in Halmahera are potential sources for novel antioxidants, according to the authors.
Verbatim
t0“Bioactivities of plant extracts collected in Halmahera”
e6“These findings indicate that collected plants from Halmahera are potential to be studied and developed further as the potential sources for novel antioxidants”