Abstract
Bridelia tomentosa Blume is a small evergreen tree which has enormous folklore applications in the treatment of colic, traumatic injury, epidemic influenza and neurasthenia. The main purpose of this study was to isolate bioactive compounds from the stem bark of B. tomentosa growing in Bangladesh. Extensive chromatographic separation and purification of the methanolic extract of stem bark of B. tomentosa led to the isolation of four compounds. The purified constituents were identified as friedoolean-5(6),14(15)-dien-3-one (1), β-taraxerol (2), D4- stigmasterone (3) and lupeol (4) by extensive analysis of NMR spectroscopic data. While compound 1 is appeared to be new, the other compounds (2-4) have been isolated for the first time from this plant. β-taraxerol (2) demonstrated significant cytotoxic activity against the brine shrimp Artemia salina and moderate to strong antimicrobial efficacy with the highest inhibitory potential against Salmonella Typhi (zone of inhibition = 21.3 mm) and Sarcina lutea (zone of inhibition =20.8 mm). In conclusion, B. tomentosa has been found to be a rich source of secondary metabolites and thus it may be studied further in order to isolate of more bioactive constituents. Dhaka Univ. J. Pharm. Sci. 20(2): 213-218, 2021 (December)
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Claims 6
Claim · model-written summary
Four compounds were isolated from Bridelia tomentosa stem bark.
- Taxon
- B. tomentosa
Bridelia tomentosae0 - Organ / stage
- stem barke0
- Outcome
- isolation of four compoundse0
- Value
- four compoundse0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Extensive chromatographic separation and purification of the methanolic extract of stem bark of B. tomentosa led to the isolation of four compounds.”
Claim · model-written summary
The four purified constituents were friedoolean-5(6),14(15)-dien-3-one, β-taraxerol, D4- stigmasterone and lupeol.
- Taxon
- Bridelia tomentosaBridelia tomentosat0
- Outcome
- friedoolean-5(6),14(15)-dien-3-one (1), β-taraxerol (2), D4- stigmasterone (3) and lupeol (4)e0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The purified constituents were identified as friedoolean-5(6),14(15)-dien-3-one (1), β-taraxerol (2), D4- stigmasterone (3) and lupeol (4) by extensive analysis of NMR spectroscopic data.”
t0“Bridelia tomentosa”
Claim · model-written summary
Compound 1 appeared new, and the other three were first isolated from this plant.
- Taxon
- Bridelia tomentosaBridelia tomentosat0
- Outcome
- compound 1 is appeared to be newe0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“While compound 1 is appeared to be new, the other compounds (2-4) have been isolated for the first time from this plant.”
t0“Bridelia tomentosa”
Claim · model-written summary
β-taraxerol showed significant cytotoxicity toward Artemia salina.
- Taxon
- Artemia salina
Artemia salinae0 - Compound
- β-taraxerole0
- Outcome
- cytotoxic activitye0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“β-taraxerol (2) demonstrated significant cytotoxic activity against the brine shrimp Artemia salina”
Claim · model-written summary
β-taraxerol inhibited Salmonella Typhi with a 21.3 mm zone.
- Taxon
- Salmonella Typhi
Salmonella enterica subsp. enterica serovar Typhie0 - Compound
- β-taraxerole0
- Outcome
- zone of inhibitione0
- Value
- 21.3 mme0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“β-taraxerol (2) demonstrated significant cytotoxic activity against the brine shrimp Artemia salina and moderate to strong antimicrobial efficacy with the highest inhibitory potential against Salmonella Typhi (zone of inhibition = 21.3 mm) and Sarcina lutea (zone of inhibition =20.8 mm).”
Claim · model-written summary
β-taraxerol inhibited Sarcina lutea with a 20.8 mm zone.
- Taxon
- Sarcina lutea
Micrococcus luteuse0 - Compound
- β-taraxerole0
- Outcome
- zone of inhibitione0
- Value
- 20.8 mme0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“β-taraxerol (2) demonstrated significant cytotoxic activity against the brine shrimp Artemia salina and moderate to strong antimicrobial efficacy with the highest inhibitory potential against Salmonella Typhi (zone of inhibition = 21.3 mm) and Sarcina lutea (zone of inhibition =20.8 mm).”