Abstract
Rehmannia glutinosa is an important medicinal plant that has long been used in Chinese traditional medicine. Acteoside, one of the bioactive components from R. glutinosa, possessed various pharmacological activities for human health; however, the molecular mechanism of acteoside formation is not fully understood. In the current study, a novel tyrosine decarboxylase (designated as RgTyDC2) was identified from the R. glutinosa transcriptome. Biochemical analysis of RgTyDC2 showed RgTyDC2 uses tyrosine and dopa as the substrate to produce tyramine and dopamine, respectively, and it displays higher catalytic efficiency toward tyrosine than dopa. Moreover, the transcript level of RgTyDC2 was consistent with the accumulation pattern of acteoside in R. glutinosa, supporting its possible role in the biosynthesis of acteoside in vivo.
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Claims 5
Claim · model-written summary
A novel tyrosine decarboxylase, RgTyDC2, was identified from the Rehmannia glutinosa transcriptome.
- Taxon
- Rehmannia glutinosa
Rehmannia glutinosae0 - Gene
- RgTyDC2e1
- Outcome
- tyrosine decarboxylasee1
- Qualifier
- novele1
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Rehmannia glutinosa is an important medicinal plant”
e1“a novel tyrosine decarboxylase (designated as RgTyDC2) was identified from the R. glutinosa transcriptome”
Claim · model-written summary
RgTyDC2 uses tyrosine and dopa as substrates to produce tyramine and dopamine.
- Taxon
- Rehmannia glutinosaRehmannia glutinosae0
- Gene
- RgTyDC2e2
- Outcome
- tyramine and dopaminee2
- Qualifier
- tyrosine and dopa as the substratee2
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Rehmannia glutinosa is an important medicinal plant”
e2“RgTyDC2 uses tyrosine and dopa as the substrate to produce tyramine and dopamine, respectively, and it displays higher catalytic efficiency toward tyrosine than dopa”
Claim · model-written summary
RgTyDC2 had higher catalytic efficiency toward tyrosine than toward dopa.
- Taxon
- Rehmannia glutinosaRehmannia glutinosae0
- Gene
- RgTyDC2e2
- Outcome
- catalytic efficiency toward tyrosinee2
- Direction
- highere2
- Comparator
- dopae2
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Rehmannia glutinosa is an important medicinal plant”
e2“RgTyDC2 uses tyrosine and dopa as the substrate to produce tyramine and dopamine, respectively, and it displays higher catalytic efficiency toward tyrosine than dopa”
Claim · model-written summary
The RgTyDC2 transcript level was consistent with the accumulation pattern of acteoside.
- Taxon
- Rehmannia glutinosaRehmannia glutinosae0
- Gene
- RgTyDC2e3
- Compound
- acteosidee3
- Outcome
- transcript levele3
- Qualifier
- consistent with the accumulation patterne3
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Rehmannia glutinosa is an important medicinal plant”
e3“the transcript level of RgTyDC2 was consistent with the accumulation pattern of acteoside in R. glutinosa”
Claim · model-written summary
RgTyDC2 may play a role in acteoside biosynthesis in vivo.
- Taxon
- Rehmannia glutinosaRehmannia glutinosae0
- Compound
- acteosidee4
- Outcome
- biosynthesis of acteosidee4
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Rehmannia glutinosa is an important medicinal plant”
e4“supporting its possible role in the biosynthesis of acteoside in vivo”