Abstract
Schinus molle is a medicinal plant used as an anti‐inflammatory and for rheumatic pain in the traditional medicine of Peru. On the other hand, Aedes aegypti is the main vector of several tropical diseases and the transmitter of yellow fever, chikungunya, malaria, dengue, and Zika virus. In this study, the aim was to investigate the antioxidant activity in vitro and the insecticidal activity in silico, in the presence of the mosquito juvenile hormone‐binding protein (mJHBP) from Aedes aegypti , of the essential oil from S. molle leaves. The volatile phytochemicals were analyzed by gas chromatography‐mass spectrometry (GC‐MS), and the profile antioxidants were examined by DPPH, ABTS, and FRAP assays. The evaluation in silico was carried out on mJHBP (PDB: 5V13) with an insecticidal approach. The results revealed that EO presented as the main volatile components to alpha‐phellandrene (32.68%), D‐limonene (12.59%), and beta‐phellandrene (12.24%). The antioxidant activity showed values for DPPH = 11.42 ± 0.08 μ mol ET/g, ABTS = 134.88 ± 4.37 μ mol ET/g, and FRAP = 65.16 ± 1.46 μ mol ET/g. Regarding the insecticidal approach in silico, alpha‐muurolene and gamma‐cadinene had the best biding energy on mJHBP ( Δ G = −9.7 kcal/mol), followed by beta‐cadinene ( Δ G = −9.5 kcal/mol). Additionally, the volatile components did not reveal antioxidant activity, and its potential insecticidal effect would be acting on mJHBP from A. aegypti.
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Claims 11
Claim · model-written summary
alpha‐phellandrene was a major volatile component of S. molle leaf oil at 32.68%.
- Taxon
- Schinus molle L.
Schinus mollet0 - Organ / stage
- Leavest0
- Outcome
- alpha‐phellandrenee0
- Value
- 32.68%e0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The results revealed that EO presented as the main volatile components to alpha‐phellandrene (32.68%), D‐limonene (12.59%), and beta‐phellandrene (12.24%).”
t0“Schinus molle L. Leaves”
Claim · model-written summary
D‐limonene was a major volatile component of S. molle leaf oil at 12.59%.
- Taxon
- Schinus molle L.Schinus mollet0
- Organ / stage
- Leavest0
- Outcome
- D‐limonenee0
- Value
- 12.59%e0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The results revealed that EO presented as the main volatile components to alpha‐phellandrene (32.68%), D‐limonene (12.59%), and beta‐phellandrene (12.24%).”
t0“Schinus molle L. Leaves”
Claim · model-written summary
beta‐phellandrene was a major volatile component of S. molle leaf oil at 12.24%.
- Taxon
- Schinus molle L.Schinus mollet0
- Organ / stage
- Leavest0
- Outcome
- beta‐phellandrenee0
- Value
- 12.24%e0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The results revealed that EO presented as the main volatile components to alpha‐phellandrene (32.68%), D‐limonene (12.59%), and beta‐phellandrene (12.24%).”
t0“Schinus molle L. Leaves”
Claim · model-written summary
Leaf oil antioxidant activity by DPPH was 11.42 ± 0.08 μ mol ET/g.
- Taxon
- Schinus molle L.Schinus mollet0
- Outcome
- DPPHe0
- Value
- 11.42 ± 0.08 μ mol ET/ge0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The antioxidant activity showed values for DPPH = 11.42 ± 0.08 μ mol ET/g, ABTS = 134.88 ± 4.37 μ mol ET/g, and FRAP = 65.16 ± 1.46 μ mol ET/g.”
t0“Schinus molle L. Leaves”
Claim · model-written summary
Leaf oil antioxidant activity by ABTS was 134.88 ± 4.37 μ mol ET/g.
- Taxon
- Schinus molle L.Schinus mollet0
- Outcome
- ABTSe0
- Value
- 134.88 ± 4.37 μ mol ET/ge0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The antioxidant activity showed values for DPPH = 11.42 ± 0.08 μ mol ET/g, ABTS = 134.88 ± 4.37 μ mol ET/g, and FRAP = 65.16 ± 1.46 μ mol ET/g.”
t0“Schinus molle L. Leaves”
Claim · model-written summary
Leaf oil antioxidant activity by FRAP was 65.16 ± 1.46 μ mol ET/g.
- Taxon
- Schinus molle L.Schinus mollet0
- Outcome
- FRAPe0
- Value
- 65.16 ± 1.46 μ mol ET/ge0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The antioxidant activity showed values for DPPH = 11.42 ± 0.08 μ mol ET/g, ABTS = 134.88 ± 4.37 μ mol ET/g, and FRAP = 65.16 ± 1.46 μ mol ET/g.”
t0“Schinus molle L. Leaves”
Claim · model-written summary
alpha‐muurolene had modeled mJHBP binding energy of −9.7 kcal/mol.
- Taxon
- Aedes aegypti
Aedes aegyptit0 - Gene
- mJHBPe0
- Compound
- alpha‐muurolenee0
- Outcome
- biding energy on mJHBPe0
- Value
- −9.7 kcal/mole0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Regarding the insecticidal approach in silico, alpha‐muurolene and gamma‐cadinene had the best biding energy on mJHBP ( Δ G = −9.7 kcal/mol), followed by beta‐cadinene ( Δ G = −9.5 kcal/mol).”
t0“Aedes aegypti”
Claim · model-written summary
gamma‐cadinene had modeled mJHBP binding energy of −9.7 kcal/mol.
- Taxon
- Aedes aegyptiAedes aegyptit0
- Gene
- mJHBPe0
- Compound
- gamma‐cadinenee0
- Outcome
- biding energy on mJHBPe0
- Value
- −9.7 kcal/mole0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Regarding the insecticidal approach in silico, alpha‐muurolene and gamma‐cadinene had the best biding energy on mJHBP ( Δ G = −9.7 kcal/mol), followed by beta‐cadinene ( Δ G = −9.5 kcal/mol).”
t0“Aedes aegypti”
Claim · model-written summary
beta‐cadinene had modeled mJHBP binding energy of −9.5 kcal/mol.
- Taxon
- Aedes aegyptiAedes aegyptit0
- Gene
- mJHBPe0
- Compound
- beta‐cadinenee0
- Outcome
- biding energy on mJHBPe0
- Value
- −9.5 kcal/mole0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Regarding the insecticidal approach in silico, alpha‐muurolene and gamma‐cadinene had the best biding energy on mJHBP ( Δ G = −9.7 kcal/mol), followed by beta‐cadinene ( Δ G = −9.5 kcal/mol).”
t0“Aedes aegypti”
Claim · model-written summary
Individual volatile components did not show antioxidant activity.
Not reportedTaxon
Verbatim
e0“Additionally, the volatile components did not reveal antioxidant activity, and its potential insecticidal effect would be acting on mJHBP from A. aegypti.”
Claim · model-written summary
The authors suggest that the potential insecticidal effect acts through A. aegypti mJHBP.
- Taxon
- A. aegyptiAedes aegyptie0
- Gene
- mJHBPe0
- Outcome
- potential insecticidal effecte0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Additionally, the volatile components did not reveal antioxidant activity, and its potential insecticidal effect would be acting on mJHBP from A. aegypti.”