Abstract
Cancer is a multifactorial organic dysfunction for which great efforts are being devoted in searching for new treatments and therapeutic adjuvants. Annona muricata is a fruit that has promising activity against several types of cancer, as it contains acetogenins, the metabolite group associated with this action. Thus, the objective of this study was to evaluate, in experimental models, the toxic behavior of an extract and fraction rich in acetogenins from A. muricata seeds and study the acetogenin, Annonacin, in silico. Phytochemical characterization was made by thin layer chromatography, spectroscopy in the infrared region and nuclear magnetic resonance. Toxicity was evaluated by tests of Allium cepa and Artemia salina, and in silico studies using the SwissDock servers DockThor, PharmMapper, ADMETLab, PreADME, Osiris and ProTox. The extract and fraction showed genotoxic activity against meristematic cells of A. cepa, reducing the mitotic index; however, the extract produced great deleterious effects on the system, even causing cell necrosis. In A. Saline, the extract was more toxic than the fraction, but both samples were considered toxic. Annonacin was effectively linked to complex I, and presented different activities regarding toxicity. Thus, the results of this study are promising, highlighting the anticancer potential of acetogenins.
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Claims 3
Claim · model-written summary
Annona muricata seed extract showed genotoxic activity in Allium cepa meristematic cells and reduced their mitotic index.
- Taxon
- A. cepa
Allium cepae0 - Organ / stage
- meristematic cellse0
- Treatment
- extracte0
- Outcome
- mitotic indexe0
- Direction
- reducinge0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The extract and fraction showed genotoxic activity against meristematic cells of A. cepa, reducing the mitotic index”
t0“Annona muricata L. Seeds”
Claim · model-written summary
The Annona muricata seed fraction showed genotoxic activity and reduced the Allium cepa mitotic index.
- Taxon
- A. cepaAllium cepae0
- Organ / stage
- meristematic cellse0
- Treatment
- fractione0
- Outcome
- mitotic indexe0
- Direction
- reducinge0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“The extract and fraction showed genotoxic activity against meristematic cells of A. cepa, reducing the mitotic index”
Claim · model-written summary
The extract caused necrosis of Allium cepa cells.
- Taxon
- A. cepaAllium cepae1
- Treatment
- extracte0
- Outcome
- cell necrosise0
Not reportedComparatorDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“the extract produced great deleterious effects on the system, even causing cell necrosis”
e1“meristematic cells of A. cepa”
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