Abstract
Hexalobus crispiflorus A. Rich., synonym Hexalobus grandiflorus Benth, is a plant in the Central African pharmacopoeia, widely used in the treatment of skin diseases and diabetes. The present study is a contribution to the qualitative and quantitative analysis and evaluation of the antioxidant activity of this plant. Preliminary phytochemical tests carried out on the different crude extracts of H. crispiflorus revealed the presence of flavonoids, anthocyanins, tannins, saponosides, triterpenes and sterols, followed by confirmation by thin layer chromatography. Quantitative analysis showed that the hydroethanolic extracts (50%) of H. crispiflorus have a high content of total polyphenols and flavonoids 955.11 ± 0.76 µg AG/g Ms and 779.85 ± 7.93 µg Eq Quer/g Ms, respectively. Hydroethanolic extract remains the best solvent for extraction of phenolic compounds. The evaluation of the free radical scavenging capacity using the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) free radical trapping method on 96-well microplates showed that only the hydroethanolic (50%, 80%) and aqueous extracts had a moderate percentage of inhibition 17.94, 19.47 and 39.85%, respectively, but this was still low compared to the reference molecule, ascorbic acid (89.4%). The results obtained could justify the therapeutic virtues of this species in the treatment of various pathologies. Key words: Hexalobus crispiflorus A. Rich, extracts, qualitative and quantitative composition, antioxidant activity.
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Claims 8
Claim · model-written summary
Crude extracts contained flavonoids, anthocyanins, tannins, saponosides, triterpenes and sterols.
- Taxon
- H. crispiflorusHexalobus crispifloruse0
- Organ / stage
- stem barkt0
- Outcome
- presence of flavonoids, anthocyanins, tannins, saponosides, triterpenes and sterolse0
Verbatim
e0“Preliminary phytochemical tests carried out on the different crude extracts of H. crispiflorus revealed the presence of flavonoids, anthocyanins, tannins, saponosides, triterpenes and sterols”
t0“stem bark of Hexalobus crispiflorus A. Rich”
Claim · model-written summary
The 50% hydroethanolic extract contained 955.11 ± 0.76 µg AG/g Ms total polyphenols.
Verbatim
e0“the hydroethanolic extracts (50%) of H. crispiflorus have a high content of total polyphenols and flavonoids 955.11 ± 0.76 µg AG/g Ms and 779.85 ± 7.93 µg Eq Quer/g Ms, respectively”
Claim · model-written summary
The 50% hydroethanolic extract contained 779.85 ± 7.93 µg Eq Quer/g Ms flavonoids.
Verbatim
e0“the hydroethanolic extracts (50%) of H. crispiflorus have a high content of total polyphenols and flavonoids 955.11 ± 0.76 µg AG/g Ms and 779.85 ± 7.93 µg Eq Quer/g Ms, respectively”
Claim · model-written summary
Hydroethanolic extract was the best solvent for phenolic compound extraction.
- Taxon
- Hexalobus crispiflorus A. RichHexalobus crispiflorust0
- Outcome
- extraction of phenolic compoundse0
- Direction
- beste0
Not reportedComparator
Verbatim
e0“Hydroethanolic extract remains the best solvent for extraction of phenolic compounds”
t0“Hexalobus crispiflorus A. Rich”
Claim · model-written summary
The 50% hydroethanolic extract had 17.94% DPPH inhibition.
Verbatim
e0“only the hydroethanolic (50%, 80%) and aqueous extracts had a moderate percentage of inhibition 17.94, 19.47 and 39.85%, respectively”
t0“Hexalobus crispiflorus A. Rich”
Claim · model-written summary
The 80% hydroethanolic extract had 19.47% DPPH inhibition.
Verbatim
e0“only the hydroethanolic (50%, 80%) and aqueous extracts had a moderate percentage of inhibition 17.94, 19.47 and 39.85%, respectively”
t0“Hexalobus crispiflorus A. Rich”
Claim · model-written summary
The aqueous extract had 39.85% DPPH inhibition.
Verbatim
e0“aqueous extracts had a moderate percentage of inhibition 17.94, 19.47 and 39.85%, respectively”
t0“Hexalobus crispiflorus A. Rich”
Claim · model-written summary
Extract inhibition was low relative to ascorbic acid at 89.4%.
Verbatim
e0“this was still low compared to the reference molecule, ascorbic acid (89.4%)”
t0“Hexalobus crispiflorus A. Rich”