By interacting organism › Viruses › Orthomyxoviridae

Intervention effectobservedoriginal resultpositivemeasured

Claim · model-written summary

Polyphenols in the ethyl acetate fraction showed high antiviral activity against H1N1 with a selective index of 23.6.

Taxon: Solidago canadensis L.Solidago canadensise0
Treatment: polyphenols in the ethyl acetate fractione2
Interactor: H1N1H1N1 subtypee2pathogen
Outcome: antiviral activities against H1N1e2
Direction: highe2
Value: 23.6e2
Qualifier: selective index (SI) = estimated CC50/estimated IC50e2

Not reportedComparator

Verbatim

e0
“Solidago canadensis L.”
✓ located verbatim in the source · abstract, characters 0–22

e2
“The polyphenols in the ethyl acetate fraction showed high antiviral activities against H1N1 with a selective index (SI) = estimated CC50/estimated IC50 = 23.6”
✓ located verbatim in the source · abstract, characters 1112–1270

Title

Phytochemical Investigation and Pharmacological Activity of Solidago canadensis L. against H1N1 Virus, involving the Separation and Identifi cation of Three New Compounds

Hayder T Hasan; Enas J Kadhim International Journal of Drug Delivery Technology 2023. doi:10.25258/ijddt.13.1.28

Other claims from this paper (2)

Intervention effectobservedoriginal resultpositivemeasured

Claim · model-written summary

Aqueous-ethanolic extracts most strongly inhibited infectivity of influenza A/Aichi/2/68 (H3N2) when M. fistulosa was collected at the growth stage.

Taxon: M. fistulosaMonarda fistulosae1
Organ / stage: growth stagee1
Treatment: aqueous-ethanolic extractse1
Interactor: Influenza virus A/Aichi/2/68 (H3N2)unidentified influenza viruse1pathogen
Outcome: infectivitye1
Direction: most strongly inhibitede1
Setting: forest-steppe zone of Western Siberiae0

Not reportedComparator

Verbatim

e0
“This is a study on antiviral activity of various extracts from the plant Monarda fistulosa L. cultivated in the forest-steppe zone of Western Siberia during the vegetation period”
✓ located verbatim in the source · abstract, characters 0–178

e1
“Influenza virus A/Aichi/2/68 (H3N2) infectivity was most strongly inhibited by aqueous-ethanolic extracts from M. fistulosa raw material collected at the growth stage”
✓ located verbatim in the source · abstract, characters 829–995

Title

MONARDA FISTULOSA L. FROM THE FOREST-STEPPE ZONE OF WESTERN SIBERIA: ANTI-INFLUENZA ACTIVITY OF PLANT COMPONENTS DURING THE VEGETATION PERIOD

I.E. LOBANOVA; M.A. PROTSENKO; T.A. KUKUSHKINA; et al. Химия в интересах устойчивого развития 2023. doi:10.15372/csd2023468

Other claims from this paper (5)

Intervention effectobservedoriginal resultpositivemeasured

Claim · model-written summary

Aqueous extract from the fruiting initiation stage most inhibited infectivity of influenza A/Aichi/2/68 (H3N2).

Taxon: M. fistulosaMonarda fistulosae1
Organ / stage: fruiting initiation stagee2
Treatment: aqueous extracte2
Interactor: Influenza virus A/Aichi/2/68 (H3N2)unidentified influenza viruse1pathogen
Outcome: infectivitye1
Direction: inhibitede1

Not reportedComparator

Verbatim

e1
“Influenza virus A/Aichi/2/68 (H3N2) infectivity was most strongly inhibited by aqueous-ethanolic extracts from M. fistulosa raw material collected at the growth stage”
✓ located verbatim in the source · abstract, characters 829–995

e2
“by the aqueous extract from the fruiting initiation stage”
✓ located verbatim in the source · abstract, characters 1000–1057

Title

MONARDA FISTULOSA L. FROM THE FOREST-STEPPE ZONE OF WESTERN SIBERIA: ANTI-INFLUENZA ACTIVITY OF PLANT COMPONENTS DURING THE VEGETATION PERIOD

I.E. LOBANOVA; M.A. PROTSENKO; T.A. KUKUSHKINA; et al. Химия в интересах устойчивого развития 2023. doi:10.15372/csd2023468

Other claims from this paper (5)

Intervention effectobservedoriginal resultpositivemeasured

Claim · model-written summary

Extracts of M. fistulosa inhibited infectivity of influenza A/chicken/Kurgan/05/2005 (H5N1) almost throughout the vegetation period.

Taxon: M. fistulosaMonarda fistulosae3
Treatment: M. fistulosa extracte3
Interactor: influenza virus A/chicken/Kurgan/05/2005 (H5N1)H5N1 subtypee3pathogen
Outcome: infectivitye3
Direction: Inhibitione3
Setting: whole vegetation periode3

Not reportedComparator

Verbatim

e3
“Inhibition of the infectivity of influenza virus A/chicken/Kurgan/05/2005 (H5N1) was achieved by one or another M. fistulosa extract almost throughout the whole vegetation period”
✓ located verbatim in the source · abstract, characters 1059–1237

Title

MONARDA FISTULOSA L. FROM THE FOREST-STEPPE ZONE OF WESTERN SIBERIA: ANTI-INFLUENZA ACTIVITY OF PLANT COMPONENTS DURING THE VEGETATION PERIOD

I.E. LOBANOVA; M.A. PROTSENKO; T.A. KUKUSHKINA; et al. Химия в интересах устойчивого развития 2023. doi:10.15372/csd2023468

Other claims from this paper (5)

Intervention effectobservedoriginal resultpositivemeasured

Claim · model-written summary

Polyphenolic Fractions 1 and 2 were more active against influenza A/Aichi/2/68 (H3N2) than aqueous and aqueous-ethanolic extracts.

Taxon: M. fistulosaMonarda fistulosae1
Treatment: Polyphenolic Fractions 1 and 2e4
Interactor: influenza virus A/Aichi/2/68 (H3N2)H3N2 subtypee4pathogen
Outcome: active against influenza virus A/Aichi/2/68 (H3N2)e4
Direction: more activee4
Comparator: aqueous and aqueous-ethanolic extractse4

Verbatim

e1
“Influenza virus A/Aichi/2/68 (H3N2) infectivity was most strongly inhibited by aqueous-ethanolic extracts from M. fistulosa raw material collected at the growth stage”
✓ located verbatim in the source · abstract, characters 829–995

e4
“It is found that Polyphenolic Fractions 1 and 2 are more active against influenza virus A/Aichi/2/68 (H3N2), but aqueous and aqueous-ethanolic extracts are more active against influenza virus A/chicken/Kurgan/05/2005 (H5N1)”
✓ located verbatim in the source · abstract, characters 1239–1462

Title

MONARDA FISTULOSA L. FROM THE FOREST-STEPPE ZONE OF WESTERN SIBERIA: ANTI-INFLUENZA ACTIVITY OF PLANT COMPONENTS DURING THE VEGETATION PERIOD

I.E. LOBANOVA; M.A. PROTSENKO; T.A. KUKUSHKINA; et al. Химия в интересах устойчивого развития 2023. doi:10.15372/csd2023468

Other claims from this paper (5)

Intervention effectobservedoriginal resultpositivemeasured

Claim · model-written summary

Aqueous and aqueous-ethanolic extracts were more active against influenza A/chicken/Kurgan/05/2005 (H5N1) than Polyphenolic Fractions 1 and 2.

Taxon: M. fistulosaMonarda fistulosae1
Treatment: aqueous and aqueous-ethanolic extractse4
Interactor: influenza virus A/chicken/Kurgan/05/2005 (H5N1)H5N1 subtypee4pathogen
Outcome: active against influenza virus A/chicken/Kurgan/05/2005 (H5N1)e4
Direction: more activee4
Comparator: Polyphenolic Fractions 1 and 2e4

Verbatim

e1
“Influenza virus A/Aichi/2/68 (H3N2) infectivity was most strongly inhibited by aqueous-ethanolic extracts from M. fistulosa raw material collected at the growth stage”
✓ located verbatim in the source · abstract, characters 829–995

e4
“It is found that Polyphenolic Fractions 1 and 2 are more active against influenza virus A/Aichi/2/68 (H3N2), but aqueous and aqueous-ethanolic extracts are more active against influenza virus A/chicken/Kurgan/05/2005 (H5N1)”
✓ located verbatim in the source · abstract, characters 1239–1462

Title

MONARDA FISTULOSA L. FROM THE FOREST-STEPPE ZONE OF WESTERN SIBERIA: ANTI-INFLUENZA ACTIVITY OF PLANT COMPONENTS DURING THE VEGETATION PERIOD

I.E. LOBANOVA; M.A. PROTSENKO; T.A. KUKUSHKINA; et al. Химия в интересах устойчивого развития 2023. doi:10.15372/csd2023468

Other claims from this paper (5)

Observationobservedoriginal resultpositivemeasured

Claim · model-written summary

The Nepeta deflersiana oil showed moderate antiviral activity against H5N1 avian influenza virus.

Taxon: Nepeta deflersianaNepeta deflersianat0
Interactor: highly pathogenic avian influenza (H5N1) virusH5N1 subtypee1pathogen
Outcome: antiviral activitye2
Qualifier: moderatee2

Verbatim

t0
“NEPETA DEFLERSIANA SCHWEINF”
✓ located verbatim in the source · title, characters 85–112

e1
“highly pathogenic avian influenza (H5N1) virus”
✓ located verbatim in the source · abstract, characters 397–443

e2
“The Nepeta deflersiana oil showed high antibacterial and moderate antiviral activity”
✓ located verbatim in the source · abstract, characters 540–624

Title

ANTIVIRAL, ANTIBACTERIAL ACTIVITIES AND CHEMICAL COMPOSITION OF THE ESSENTIAL OIL OF NEPETA DEFLERSIANA SCHWEINF GROWING IN KSA

Madiha Hassan; Nagwa Shoeib; Abeer Temraz; et al. International Research Journal of Pharmacy 2016. doi:10.7897/2230-8407.07658

Other claims from this paper (7)

Intervention effectobservedoriginal resultpositivemeasured

Claim · model-written summary

Compounds 1, 6 and 7 showed antiviral activity against influenza virus A/Hanfang/359/95 (H3N2) with IC50 values of 14.6–33.3 μM.

Taxon: Isatis indigoticaIsatis indigoticae2
Treatment: compounds 1, 6 and 7e1
Interactor: influenza virus A/Hanfang/359/95 (H3N2)H3N2 subtypee1pathogen
Outcome: antiviral activity against influenza virus A/Hanfang/359/95 (H3N2)e1
Value: 14.6-33.3 μMe1

Not reportedComparatorDirection

Verbatim

e1
“compounds 1, 6 and 7 showed antiviral activity against influenza virus A/Hanfang/359/95 (H3N2) with IC50 values of 14.6-33.3 μM”
✓ located verbatim in the source · abstract, characters 421–548

e2
“aqueous extract of the Isatis indigotica roots”
✓ located verbatim in the source · abstract, characters 136–182

Title

Indole alkaloid glucosides from the roots of Isatis indigotica

Yu-Feng Liu; Ming-Hua Chen; Sheng Lin; et al. Journal of Asian Natural Products Research 2015. doi:10.1080/10286020.2015.1117452

Other claims from this paper (2)

Intervention effectobservedoriginal resultpositivemeasured

Claim · model-written summary

Two doses of 0.5 microg of H5-VLPs conferred complete protection in mice against a lethal challenge with the heterologous A/Vietnam/1194/04 (H5N1) strain.

Taxon: Nicotiana benthamianaNicotiana benthamianae0
Treatment: two doses of 0.5 microg of H5-VLPse6
Interactor: A/Vietnam/1194/04 (H5N1)H5N1 subtypee6pathogen
Outcome: complete protection against a lethal challengee6
Direction: conferrede6
Qualifier: heterologouse6

Not reportedComparator

Verbatim

e0
“we expressed haemagglutinin (HA) from strains A/Indonesia/5/05 (H5N1) and A/New Caledonia/20/99 (H1N1) by agroinfiltration of Nicotiana benthamiana plants”
✓ located verbatim in the source · abstract, characters 502–656

e6
“two doses of 0.5 microg of H5-VLPs conferred complete protection against a lethal challenge with the heterologous A/Vietnam/1194/04 (H5N1) strain”
✓ located verbatim in the source · abstract, characters 1467–1612

Title

Influenza virus‐like particles produced by transient expression in Nicotiana benthamiana induce a protective immune response against a lethal viral challenge in mice

Marc‐André D’Aoust; Pierre‐Olivier Lavoie; Manon M.‐J. Couture; et al. Plant Biotechnology Journal 2008. doi:10.1111/j.1467-7652.2008.00384.x

Other claims from this paper (7)

Observationobservedoriginal resultpositivesignificant (as stated)measured

Claim · model-written summary

MeOH extracts of Salvia species had a significant anti-influenza virus effect.

Taxon: Salvia limbata C.A.Mey. and Salvia sclarea L.Salvia sclarea Salvia limbatat0
Material: MeOH extractse6
Interactor: influenza virusunidentified influenza viruse6pathogen
Outcome: anti-influenza virus effecte6

Verbatim

t0
“Salvia limbata C.A.Mey. and Salvia sclarea L.”
✓ located verbatim in the source · title, characters 60–105

e6
“the MeOH extracts from Salvia species had a significant anti-influenza virus effect and limited antiherpetic activity”
✓ located verbatim in the source · abstract, characters 1380–1497

Title

Bioactivities of the Various Extracts and Essential Oils of Salvia limbata C.A.Mey. and Salvia sclarea L.

Hatice Öğütçü; Atalay Sökmen; Münevver Sökmen; et al. DergiPark (Istanbul University) 2008

Other claims from this paper (10)

Orthomyxoviridae 12 claims

12 claims