Claim · model-written summary
DPS, RPG1 and RPG2 process intermediates into leptinines and leptines.
- Taxon
- potato
Solanum tuberosumt0 - Gene
- DPSe0
- Outcome
- leptinines and leptinese0
Not reportedMaterialCompoundOrgan / stageInteractorInteractor roleSecond interactorSecond interactor roleTreatmentComparatorSettingDirectionValueQualifier
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“subsequently processed into leptinines and leptines by the ring-rearrangement enzymes Dioxygenase for Potato Solanidane synthesis (DPS), Reductase for Potato Glycoalkaloid biosynthesis 1 (RPG1), and RPG2”
t0“wild potato”
Title
Ryota Akiyama; Yuki Ikeyama; Hyoung Jae Lee; et al. Proceedings of the National Academy of Sciences 2026. doi:10.1073/pnas.2537847123
Other claims from this paper (8)
- Mechanism Wild Solanum chacoense PI458310 resists Colorado potato beetle through leptine accumulation.
- Mechanism Leptinines and leptines arise from transformed spirosolane-type precursors rather than direct modification of α-chaconine/α-solanine.
- Observation Sc23DOX was identified as a spirosolane C-23 hydroxylase.
- Observation Sc23ACT was identified as a 23-O-acetyltransferase.
- Mechanism Sc23DOX and Sc23ACT convert α/β-solamarine into hydroxylated and acetylated intermediates in vitro.
- Intervention effect Heterologous Sc23DOX and Sc23ACT expression produced leptinines and leptines de novo in cultivated potato.
- Observation Many cultivated potatoes retain apparently functional 23DOX and 23ACT orthologues.
- Intervention effect Expression of 23DOX alone restores leptine biosynthesis in some cultivars.