Claim · model-written summary
FgIsw1 emerged as a key chromatin accessibility regulator.
- Taxon
- Fusarium graminearum
_on_Corn_(Zea_mays)_at_Waimea%2C_Hawaii.jpg?width=60)
Fusarium graminearume1 - Gene
- FgIsw1e0
- Outcome
- key regulatore0
Not reportedMaterialCompoundOrgan / stageInteractorInteractor roleSecond interactorSecond interactor roleTreatmentComparatorSettingDirectionValueQualifier
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
_on_Corn_(Zea_mays)_at_Waimea%2C_Hawaii.jpg?width=500)
Verbatim
e0“Putrescine globally alters chromatin accessibility, with the ATP-dependent chromatin remodeler FgIsw1 emerging as a key regulator.”
e1“the phytopathogenic fungus Fusarium graminearum”
Title
Fungal chromatin remodeler Isw1 modulates translation via regulating tRNA transcription
Jing Wang; Yueqi Zhang; Jingrui Wang; et al. Nucleic Acids Research 2025. doi:10.1093/nar/gkaf225
Other claims from this paper (7)
- Observation Putrescine globally changed fungal chromatin accessibility.
- Intervention effect FgIsw1 deletion did not affect DON biosynthesis gene transcription.
- Intervention effect FgIsw1 deletion significantly disrupted tRNA transcription.
- Intervention effect FgIsw1 deletion caused a dramatic decline in translation of DON biosynthesis enzymes.
- Mechanism FgIsw1 maintains nucleosome phasing in tRNA chromatin regions for efficient tRNA transcription.
- Intervention effect The FgIsw1 deletion strain was unable to produce DON.
- Intervention effect The FgIsw1 deletion strain lost virulence on the host plant.