Claim · model-written summary
EECP reduced CCI-induced hyperalgesia and mechanical allodynia.
RattusNot reportedMaterialGeneCompoundOrgan / stageInteractorInteractor roleSecond interactorSecond interactor roleComparatorSettingValueQualifier
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“the EECP reduced CCI-induced hyperalgesia and mechanical allodynia”
e1“neuropathic pain in rats”
Title
Ashutosh Kumar; Brijesh Kumar; Rajesh Kumar; et al. Pharmacological Research - Modern Chinese Medicine 2025. doi:10.1016/j.prmcm.2025.100624
Other claims from this paper (15)
- Observation GCMS identified Lupeool, acetate, n-hexadecanoic acid, and γ-sitosterol in the flower extract.
- Observation GCMS identified hexadecanoic acid methyl ester and Octadecenoic acid (Z)-, methyl ester in the flower extract.
- Observation GCMS identified β-Amyrin, phytol, and other compounds in the flower extract.
- Intervention effect EECP showed a significant anticonvulsant effect in rats.
- Intervention effect EECP decreased locomotor activity, interpreted as sedation.
- Intervention effect EECP showed no anxiolytic effect.
- Intervention effect EECP significantly decreased immobility time in forced swim and tail suspension tests.
- Intervention effect EECP decreased brain acetylcholinesterase activity.
- Intervention effect EECP shortened escape latency in the Morris water test.
- Intervention effect EECP increased time spent in the target quadrant in the Morris water test.
- Intervention effect EECP reduced sciatic nerve TNF-α, IL-1β, and IL-6 levels.
- Intervention effect EECP increased sciatic nerve SOD levels.
- Intervention effect EECP decreased sciatic nerve nitrite levels.
- Intervention effect EECP reduced sciatic nerve deformity on histological analysis.
- Mechanism The authors suggest that the identified phytocompounds may account for the extract's neuropharmacological and analgesic activities through neuroprotective, antioxidant, and anti-inflammatory properties.