Rattus 109 claims

genus · family Muridae · animal · NCBI Taxonomy ↗

Common name: rats — Also written in claims: rats · rat

2 spellings

Questions studied on this organism1 question4 papers

Rattus · picture of the genus (one of its species)Reg Mckenna · CC BY 2.0 · Wikimedia Commons ↗

109 claims

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Intervention effectobservedoriginal resultpositivesignificant (as stated)measured

Claim · model-written summary

MDCR caused significant vasorelaxation in precontracted rat aorta with EC50 of 3.83 ± 0.81 µg/mL.

Taxon: ratRattuse0
Organ / stage: aorta ringse0
Treatment: MDCRe0
Outcome: vasorelaxant effectse0
Value: 3.83 ± 0.81 µg/mLe0
Qualifier: phenylephrine-precontractede0

Not reportedComparatorDirection

Verbatim

e0
“significant vasorelaxant effects on phenylephrine-precontracted rat aorta rings, with EC50 values of 3.83 ± 0.81 µg/mL for MDCR and 4.87 ± 0.79 µg/mL for DDCR”
✓ located verbatim in the source · abstract, characters 1285–1443

Title

Sustainable Use of Natural Resources and Traditional Medicine in Tropical Countries: Uncovering the Main Antioxidant Compounds and Antihypertensive Potential of the Diospyros comorensis Leaves as Health-Promoting Food Application for Local Population

Ahmed Ali; Dario Donno; Zoarilala Rinah Razafindrakoto; et al. Plants 2026. doi:10.3390/plants15111757

Other claims from this paper (10)

Observation Leaf extracts had total phenolic content of 29,693.02 ± 3493.75 mg GAE/100 g DW, higher than HPLC quantification.
Observation HPLC quantified total phenolics at 3743.12 ± 457.32 mg/100 g DW.
Observation HPLC-quantified phenolics represented 76.38% of the total bioactive fraction.
Observation Ellagic acid was the main quantified constituent at 56.36%.
Observation Both leaf extracts exhibited marked antioxidant capacity.
Intervention effect DDCR caused significant vasorelaxation in precontracted rat aorta with EC50 of 4.87 ± 0.79 µg/mL.
Observation Neither extract showed acute toxicity in Swiss mice.
Mechanism Identified compounds may contribute to antioxidant and pharmacological effects.
Recommendation The results support traditional use of leaves for high blood pressure management.
Recommendation Further studies are needed on mechanisms and bioactive substances.

Intervention effectobservedoriginal resultpositivesignificant (as stated)measured

Claim · model-written summary

DDCR caused significant vasorelaxation in precontracted rat aorta with EC50 of 4.87 ± 0.79 µg/mL.

Taxon: ratRattuse0
Organ / stage: aorta ringse0
Treatment: DDCRe0
Outcome: vasorelaxant effectse0
Value: 4.87 ± 0.79 µg/mLe0
Qualifier: phenylephrine-precontractede0

Not reportedComparatorDirection

Verbatim

e0
“significant vasorelaxant effects on phenylephrine-precontracted rat aorta rings, with EC50 values of 3.83 ± 0.81 µg/mL for MDCR and 4.87 ± 0.79 µg/mL for DDCR”
✓ located verbatim in the source · abstract, characters 1285–1443

Title

Ahmed Ali; Dario Donno; Zoarilala Rinah Razafindrakoto; et al. Plants 2026. doi:10.3390/plants15111757

Other claims from this paper (10)

Observation Leaf extracts had total phenolic content of 29,693.02 ± 3493.75 mg GAE/100 g DW, higher than HPLC quantification.
Observation HPLC quantified total phenolics at 3743.12 ± 457.32 mg/100 g DW.
Observation HPLC-quantified phenolics represented 76.38% of the total bioactive fraction.
Observation Ellagic acid was the main quantified constituent at 56.36%.
Observation Both leaf extracts exhibited marked antioxidant capacity.
Intervention effect MDCR caused significant vasorelaxation in precontracted rat aorta with EC50 of 3.83 ± 0.81 µg/mL.
Observation Neither extract showed acute toxicity in Swiss mice.
Mechanism Identified compounds may contribute to antioxidant and pharmacological effects.
Recommendation The results support traditional use of leaves for high blood pressure management.
Recommendation Further studies are needed on mechanisms and bioactive substances.

Intervention effectobservedoriginal resultpositivesignificant (as stated)measured

Claim · model-written summary

EECP showed a significant anticonvulsant effect in rats.

Taxon: ratsRattuse1
Treatment: EECPe0
Outcome: anticonvulsant effecte0

Not reportedComparatorDirection

Verbatim

e0
“EECP had a significant anticonvulsant effect”
✓ located verbatim in the source · abstract, characters 1648–1692

e1
“neuropathic pain in rats”
✓ located verbatim in the source · abstract, characters 633–657

Title

Analysis of potential neuropharmacological activity and attenuating effect in chronic constriction induced neuropathic pain using Calotropis procera (Aiton) Dryand flower ethanol extract

Ashutosh Kumar; Brijesh Kumar; Rajesh Kumar; et al. Pharmacological Research - Modern Chinese Medicine 2025. doi:10.1016/j.prmcm.2025.100624

Other claims from this paper (15)

Observation GCMS identified Lupeool, acetate, n-hexadecanoic acid, and γ-sitosterol in the flower extract.
Observation GCMS identified hexadecanoic acid methyl ester and Octadecenoic acid (Z)-, methyl ester in the flower extract.
Observation GCMS identified β-Amyrin, phytol, and other compounds in the flower extract.
Intervention effect EECP decreased locomotor activity, interpreted as sedation.
Intervention effect EECP showed no anxiolytic effect.
Intervention effect EECP significantly decreased immobility time in forced swim and tail suspension tests.
Intervention effect EECP decreased brain acetylcholinesterase activity.
Intervention effect EECP shortened escape latency in the Morris water test.
Intervention effect EECP increased time spent in the target quadrant in the Morris water test.
Intervention effect EECP reduced CCI-induced hyperalgesia and mechanical allodynia.
Intervention effect EECP reduced sciatic nerve TNF-α, IL-1β, and IL-6 levels.
Intervention effect EECP increased sciatic nerve SOD levels.
Intervention effect EECP decreased sciatic nerve nitrite levels.
Intervention effect EECP reduced sciatic nerve deformity on histological analysis.
Mechanism The authors suggest that the identified phytocompounds may account for the extract's neuropharmacological and analgesic activities through neuroprotective, antioxidant, and anti-inflammatory properties.

Intervention effectobservedoriginal resultmeasured

Claim · model-written summary

EECP decreased locomotor activity, interpreted as sedation.

Taxon: ratsRattuse1
Treatment: EECPe0
Outcome: locomotor activitye0
Direction: decreasee0
Qualifier: indicating a sedative effecte0

Not reportedComparator

Verbatim

e0
“EECP had a significant anticonvulsant effect, a decrease in locomotor activity, indicating a sedative effect but showed no anxiolytic effect.”
✓ located verbatim in the source · abstract, characters 1648–1789

e1
“neuropathic pain in rats”
✓ located verbatim in the source · abstract, characters 633–657

Title

Analysis of potential neuropharmacological activity and attenuating effect in chronic constriction induced neuropathic pain using Calotropis procera (Aiton) Dryand flower ethanol extract

Ashutosh Kumar; Brijesh Kumar; Rajesh Kumar; et al. Pharmacological Research - Modern Chinese Medicine 2025. doi:10.1016/j.prmcm.2025.100624

Other claims from this paper (15)

Observation GCMS identified Lupeool, acetate, n-hexadecanoic acid, and γ-sitosterol in the flower extract.
Observation GCMS identified hexadecanoic acid methyl ester and Octadecenoic acid (Z)-, methyl ester in the flower extract.
Observation GCMS identified β-Amyrin, phytol, and other compounds in the flower extract.
Intervention effect EECP showed a significant anticonvulsant effect in rats.
Intervention effect EECP showed no anxiolytic effect.
Intervention effect EECP significantly decreased immobility time in forced swim and tail suspension tests.
Intervention effect EECP decreased brain acetylcholinesterase activity.
Intervention effect EECP shortened escape latency in the Morris water test.
Intervention effect EECP increased time spent in the target quadrant in the Morris water test.
Intervention effect EECP reduced CCI-induced hyperalgesia and mechanical allodynia.
Intervention effect EECP reduced sciatic nerve TNF-α, IL-1β, and IL-6 levels.
Intervention effect EECP increased sciatic nerve SOD levels.
Intervention effect EECP decreased sciatic nerve nitrite levels.
Intervention effect EECP reduced sciatic nerve deformity on histological analysis.
Mechanism The authors suggest that the identified phytocompounds may account for the extract's neuropharmacological and analgesic activities through neuroprotective, antioxidant, and anti-inflammatory properties.

Intervention effectobservedoriginal resultno effectmeasured

Claim · model-written summary

EECP showed no anxiolytic effect.

Taxon: ratsRattuse1
Treatment: EECPe0
Outcome: anxiolytic effecte0
Direction: noe0

Not reportedComparator

Verbatim

e0
“EECP had a significant anticonvulsant effect, a decrease in locomotor activity, indicating a sedative effect but showed no anxiolytic effect.”
✓ located verbatim in the source · abstract, characters 1648–1789

e1
“neuropathic pain in rats”
✓ located verbatim in the source · abstract, characters 633–657

Title

Analysis of potential neuropharmacological activity and attenuating effect in chronic constriction induced neuropathic pain using Calotropis procera (Aiton) Dryand flower ethanol extract

Ashutosh Kumar; Brijesh Kumar; Rajesh Kumar; et al. Pharmacological Research - Modern Chinese Medicine 2025. doi:10.1016/j.prmcm.2025.100624

Other claims from this paper (15)

Observation GCMS identified Lupeool, acetate, n-hexadecanoic acid, and γ-sitosterol in the flower extract.
Observation GCMS identified hexadecanoic acid methyl ester and Octadecenoic acid (Z)-, methyl ester in the flower extract.
Observation GCMS identified β-Amyrin, phytol, and other compounds in the flower extract.
Intervention effect EECP showed a significant anticonvulsant effect in rats.
Intervention effect EECP decreased locomotor activity, interpreted as sedation.
Intervention effect EECP significantly decreased immobility time in forced swim and tail suspension tests.
Intervention effect EECP decreased brain acetylcholinesterase activity.
Intervention effect EECP shortened escape latency in the Morris water test.
Intervention effect EECP increased time spent in the target quadrant in the Morris water test.
Intervention effect EECP reduced CCI-induced hyperalgesia and mechanical allodynia.
Intervention effect EECP reduced sciatic nerve TNF-α, IL-1β, and IL-6 levels.
Intervention effect EECP increased sciatic nerve SOD levels.
Intervention effect EECP decreased sciatic nerve nitrite levels.
Intervention effect EECP reduced sciatic nerve deformity on histological analysis.
Mechanism The authors suggest that the identified phytocompounds may account for the extract's neuropharmacological and analgesic activities through neuroprotective, antioxidant, and anti-inflammatory properties.

Intervention effectobservedoriginal resultpositivesignificant (as stated)measured

Claim · model-written summary

EECP significantly decreased immobility time in forced swim and tail suspension tests.

Taxon: ratsRattuse2
Treatment: EECPe1
Outcome: immobility timee0
Direction: decreasede0
Qualifier: both the forced swim test and tail suspension teste0

Not reportedComparator

Verbatim

e0
“The immobility time decreased significantly in both the forced swim test and tail suspension test.”
✓ located verbatim in the source · abstract, characters 1790–1888

e1
“EECP had a significant anticonvulsant effect”
✓ located verbatim in the source · abstract, characters 1648–1692

e2
“neuropathic pain in rats”
✓ located verbatim in the source · abstract, characters 633–657

Title

Analysis of potential neuropharmacological activity and attenuating effect in chronic constriction induced neuropathic pain using Calotropis procera (Aiton) Dryand flower ethanol extract

Ashutosh Kumar; Brijesh Kumar; Rajesh Kumar; et al. Pharmacological Research - Modern Chinese Medicine 2025. doi:10.1016/j.prmcm.2025.100624

Other claims from this paper (15)

Observation GCMS identified Lupeool, acetate, n-hexadecanoic acid, and γ-sitosterol in the flower extract.
Observation GCMS identified hexadecanoic acid methyl ester and Octadecenoic acid (Z)-, methyl ester in the flower extract.
Observation GCMS identified β-Amyrin, phytol, and other compounds in the flower extract.
Intervention effect EECP showed a significant anticonvulsant effect in rats.
Intervention effect EECP decreased locomotor activity, interpreted as sedation.
Intervention effect EECP showed no anxiolytic effect.
Intervention effect EECP decreased brain acetylcholinesterase activity.
Intervention effect EECP shortened escape latency in the Morris water test.
Intervention effect EECP increased time spent in the target quadrant in the Morris water test.
Intervention effect EECP reduced CCI-induced hyperalgesia and mechanical allodynia.
Intervention effect EECP reduced sciatic nerve TNF-α, IL-1β, and IL-6 levels.
Intervention effect EECP increased sciatic nerve SOD levels.
Intervention effect EECP decreased sciatic nerve nitrite levels.
Intervention effect EECP reduced sciatic nerve deformity on histological analysis.
Mechanism The authors suggest that the identified phytocompounds may account for the extract's neuropharmacological and analgesic activities through neuroprotective, antioxidant, and anti-inflammatory properties.

Intervention effectobservedoriginal resultpositivemeasured

Claim · model-written summary

EECP decreased brain acetylcholinesterase activity.

Taxon: ratsRattuse2
Organ / stage: braine0
Treatment: EECPe1
Gene: acetylcholinesterasee0
Outcome: activity of acetylcholinesterasee0
Direction: decreasede0

Not reportedComparator

Verbatim

e0
“The activity of acetylcholinesterase in the brain was decreased”
✓ located verbatim in the source · abstract, characters 1889–1952

e1
“EECP had a significant anticonvulsant effect”
✓ located verbatim in the source · abstract, characters 1648–1692

e2
“neuropathic pain in rats”
✓ located verbatim in the source · abstract, characters 633–657

Title

Analysis of potential neuropharmacological activity and attenuating effect in chronic constriction induced neuropathic pain using Calotropis procera (Aiton) Dryand flower ethanol extract

Ashutosh Kumar; Brijesh Kumar; Rajesh Kumar; et al. Pharmacological Research - Modern Chinese Medicine 2025. doi:10.1016/j.prmcm.2025.100624

Other claims from this paper (15)

Observation GCMS identified Lupeool, acetate, n-hexadecanoic acid, and γ-sitosterol in the flower extract.
Observation GCMS identified hexadecanoic acid methyl ester and Octadecenoic acid (Z)-, methyl ester in the flower extract.
Observation GCMS identified β-Amyrin, phytol, and other compounds in the flower extract.
Intervention effect EECP showed a significant anticonvulsant effect in rats.
Intervention effect EECP decreased locomotor activity, interpreted as sedation.
Intervention effect EECP showed no anxiolytic effect.
Intervention effect EECP significantly decreased immobility time in forced swim and tail suspension tests.
Intervention effect EECP shortened escape latency in the Morris water test.
Intervention effect EECP increased time spent in the target quadrant in the Morris water test.
Intervention effect EECP reduced CCI-induced hyperalgesia and mechanical allodynia.
Intervention effect EECP reduced sciatic nerve TNF-α, IL-1β, and IL-6 levels.
Intervention effect EECP increased sciatic nerve SOD levels.
Intervention effect EECP decreased sciatic nerve nitrite levels.
Intervention effect EECP reduced sciatic nerve deformity on histological analysis.
Mechanism The authors suggest that the identified phytocompounds may account for the extract's neuropharmacological and analgesic activities through neuroprotective, antioxidant, and anti-inflammatory properties.

Intervention effectobservedoriginal resultpositivemeasured

Claim · model-written summary

EECP shortened escape latency in the Morris water test.

Taxon: ratsRattuse2
Treatment: EECPe1
Outcome: escape latencye0
Direction: shortere0

Not reportedComparator

Verbatim

e0
“Morris water test results revealed a shorter escape latency and greater time spent in the target quadrant”
✓ located verbatim in the source · abstract, characters 1957–2062

e1
“EECP had a significant anticonvulsant effect”
✓ located verbatim in the source · abstract, characters 1648–1692

e2
“neuropathic pain in rats”
✓ located verbatim in the source · abstract, characters 633–657

Title

Analysis of potential neuropharmacological activity and attenuating effect in chronic constriction induced neuropathic pain using Calotropis procera (Aiton) Dryand flower ethanol extract

Ashutosh Kumar; Brijesh Kumar; Rajesh Kumar; et al. Pharmacological Research - Modern Chinese Medicine 2025. doi:10.1016/j.prmcm.2025.100624

Other claims from this paper (15)

Observation GCMS identified Lupeool, acetate, n-hexadecanoic acid, and γ-sitosterol in the flower extract.
Observation GCMS identified hexadecanoic acid methyl ester and Octadecenoic acid (Z)-, methyl ester in the flower extract.
Observation GCMS identified β-Amyrin, phytol, and other compounds in the flower extract.
Intervention effect EECP showed a significant anticonvulsant effect in rats.
Intervention effect EECP decreased locomotor activity, interpreted as sedation.
Intervention effect EECP showed no anxiolytic effect.
Intervention effect EECP significantly decreased immobility time in forced swim and tail suspension tests.
Intervention effect EECP decreased brain acetylcholinesterase activity.
Intervention effect EECP increased time spent in the target quadrant in the Morris water test.
Intervention effect EECP reduced CCI-induced hyperalgesia and mechanical allodynia.
Intervention effect EECP reduced sciatic nerve TNF-α, IL-1β, and IL-6 levels.
Intervention effect EECP increased sciatic nerve SOD levels.
Intervention effect EECP decreased sciatic nerve nitrite levels.
Intervention effect EECP reduced sciatic nerve deformity on histological analysis.
Mechanism The authors suggest that the identified phytocompounds may account for the extract's neuropharmacological and analgesic activities through neuroprotective, antioxidant, and anti-inflammatory properties.

Intervention effectobservedoriginal resultpositivemeasured

Claim · model-written summary

EECP increased time spent in the target quadrant in the Morris water test.

Taxon: ratsRattuse2
Treatment: EECPe1
Outcome: time spent in the target quadrante0
Direction: greatere0

Not reportedComparator

Verbatim

e0
“Morris water test results revealed a shorter escape latency and greater time spent in the target quadrant”
✓ located verbatim in the source · abstract, characters 1957–2062

e1
“EECP had a significant anticonvulsant effect”
✓ located verbatim in the source · abstract, characters 1648–1692

e2
“neuropathic pain in rats”
✓ located verbatim in the source · abstract, characters 633–657

Title

Analysis of potential neuropharmacological activity and attenuating effect in chronic constriction induced neuropathic pain using Calotropis procera (Aiton) Dryand flower ethanol extract

Ashutosh Kumar; Brijesh Kumar; Rajesh Kumar; et al. Pharmacological Research - Modern Chinese Medicine 2025. doi:10.1016/j.prmcm.2025.100624

Other claims from this paper (15)

Observation GCMS identified Lupeool, acetate, n-hexadecanoic acid, and γ-sitosterol in the flower extract.
Observation GCMS identified hexadecanoic acid methyl ester and Octadecenoic acid (Z)-, methyl ester in the flower extract.
Observation GCMS identified β-Amyrin, phytol, and other compounds in the flower extract.
Intervention effect EECP showed a significant anticonvulsant effect in rats.
Intervention effect EECP decreased locomotor activity, interpreted as sedation.
Intervention effect EECP showed no anxiolytic effect.
Intervention effect EECP significantly decreased immobility time in forced swim and tail suspension tests.
Intervention effect EECP decreased brain acetylcholinesterase activity.
Intervention effect EECP shortened escape latency in the Morris water test.
Intervention effect EECP reduced CCI-induced hyperalgesia and mechanical allodynia.
Intervention effect EECP reduced sciatic nerve TNF-α, IL-1β, and IL-6 levels.
Intervention effect EECP increased sciatic nerve SOD levels.
Intervention effect EECP decreased sciatic nerve nitrite levels.
Intervention effect EECP reduced sciatic nerve deformity on histological analysis.
Mechanism The authors suggest that the identified phytocompounds may account for the extract's neuropharmacological and analgesic activities through neuroprotective, antioxidant, and anti-inflammatory properties.

Intervention effectobservedoriginal resultpositivemeasured

Claim · model-written summary

EECP reduced CCI-induced hyperalgesia and mechanical allodynia.

Taxon: ratsRattuse1
Treatment: EECPe0
Outcome: CCI-induced hyperalgesia and mechanical allodyniae0
Direction: reducede0

Not reportedComparator

Verbatim

e0
“the EECP reduced CCI-induced hyperalgesia and mechanical allodynia”
✓ located verbatim in the source · abstract, characters 2101–2167

e1
“neuropathic pain in rats”
✓ located verbatim in the source · abstract, characters 633–657

Title

Analysis of potential neuropharmacological activity and attenuating effect in chronic constriction induced neuropathic pain using Calotropis procera (Aiton) Dryand flower ethanol extract

Ashutosh Kumar; Brijesh Kumar; Rajesh Kumar; et al. Pharmacological Research - Modern Chinese Medicine 2025. doi:10.1016/j.prmcm.2025.100624

Other claims from this paper (15)

Observation GCMS identified Lupeool, acetate, n-hexadecanoic acid, and γ-sitosterol in the flower extract.
Observation GCMS identified hexadecanoic acid methyl ester and Octadecenoic acid (Z)-, methyl ester in the flower extract.
Observation GCMS identified β-Amyrin, phytol, and other compounds in the flower extract.
Intervention effect EECP showed a significant anticonvulsant effect in rats.
Intervention effect EECP decreased locomotor activity, interpreted as sedation.
Intervention effect EECP showed no anxiolytic effect.
Intervention effect EECP significantly decreased immobility time in forced swim and tail suspension tests.
Intervention effect EECP decreased brain acetylcholinesterase activity.
Intervention effect EECP shortened escape latency in the Morris water test.
Intervention effect EECP increased time spent in the target quadrant in the Morris water test.
Intervention effect EECP reduced sciatic nerve TNF-α, IL-1β, and IL-6 levels.
Intervention effect EECP increased sciatic nerve SOD levels.
Intervention effect EECP decreased sciatic nerve nitrite levels.
Intervention effect EECP reduced sciatic nerve deformity on histological analysis.
Mechanism The authors suggest that the identified phytocompounds may account for the extract's neuropharmacological and analgesic activities through neuroprotective, antioxidant, and anti-inflammatory properties.