Claim · model-written summary
PRP4KA-mediated phosphorylation of LRP at serine 17 is essential to prevent FLC chromatin looping.
- Taxon
- Arabidopsis thaliana
Arabidopsis thalianae1 - Gene
- LRPe0
- Outcome
- FLC chromatin loopinge0
- Direction
- preventinge0
- Qualifier
- phosphorylation of LRP at serine 17e0
Not reportedMaterialCompoundOrgan / stageInteractorInteractor roleSecond interactorSecond interactor roleTreatmentComparatorSettingValue
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“site-specific phosphorylation of LRP at serine 17, mediated by the kinase PRP4KA, is essential for LRP protein stability and its function in preventing FLC chromatin looping and Pol II recruitment”
e1“Arabidopsis thaliana”
Title
Site-specific phosphorylation of LRP regulates FLC chromatin looping and flowering
Sheng Fan; Yu Zhang; Shaobo Zhu; et al. Science Advances 2026. doi:10.1126/sciadv.adz0645
Other claims from this paper (7)
- Mechanism LRP prevents FLC chromatin looping through association with the 5′ and 3′ genomic regions.
- Intervention effect Loss of LRP function increased FLC gene looping.
- Intervention effect Loss of LRP function reduced RNA polymerase II occupancy at FLC.
- Intervention effect Loss of LRP function increased FLC transcription.
- Intervention effect Loss of LRP function delayed flowering.
- Mechanism PRP4KA mediates LRP phosphorylation at serine 17, which is essential for LRP protein stability.
- Mechanism PRP4KA-mediated phosphorylation of LRP at serine 17 is essential for its function in preventing Pol II recruitment.