Intervention effectmodel-written summary

Geminivirus infection upregulated MEL expression.

A claim from The Nicotiana benthamiana microtubule-associated E3 ubiquitin ligase degrades a host immune regulator and a viral effector to enhance antiviral defense · 2025

Intervention effectobservedoriginal resultpositivemeasured

Claim · model-written summary

Geminivirus infection upregulated MEL expression.

Taxon
Nicotiana benthamianaNicotiana benthamianat0
Treatment
Geminivirus infectione0
Outcome
expression of plant microtubule-associated E3 ligase ( MEL )e0
Direction
upregulatione0

Not reportedMaterialGeneCompoundOrgan / stageInteractorInteractor roleSecond interactorSecond interactor roleComparatorSettingValueQualifier

Organisms pictured · Representative pictures of the matched species, not figures from the paper.

Nicotiana benthamiana
Nicotiana benthamiana · TaxonCharles Andres · CC BY-SA 3.0 · Wikimedia Commons ↗

Verbatim

e0

“Geminivirus infection activates the upregulation expression of plant microtubule-associated E3 ligase ( MEL )”

✓ located verbatim in the source · abstract, characters 2–111
t0

“Nicotiana benthamiana”

✓ located verbatim in the source · title, characters 4–25

Title

The Nicotiana benthamiana microtubule-associated E3 ubiquitin ligase degrades a host immune regulator and a viral effector to enhance antiviral defense

Kun Wang; Shuai Fu; Yuchong Tan; et al. Journal of Integrative Agriculture 2025. doi:10.1016/j.jia.2025.10.022

Other claims from this paper (2)

Record rev-21383f92e4dbb7514a26ed0ebc6005efc4b46203aa52d219559b6a6849b7ffa7 · schema claims-v0.9 · position 1 in the model’s answer

infection · molecular: expression · Nicotiana benthamianaPositive and negative results

10 papers: 5 positive, 5 negative or no effect

4 papers in the same direction as this claim · 5 in the opposite direction

  1. negative
    At least one CesA family member had lower transcript levels in infected plants.

    Virus-Induced Silencing of a Plant Cellulose Synthase Gene · 2000

    Opposite direction

  2. no effect
    Expression of key chlorophyll degradation genes remained unaffected.

    A geminivirus betasatellite damages the structural and functional integrity of chloroplasts leading to symptom formation and inhibition of photosynthesis · 2015

    Opposite direction

  3. negative
    ToLCNDV‐OM infection reduced host NbFKPPIase expression.

    FKBP‐type peptidyl‐prolyl cis‐trans isomerase interacts with the movement protein of tomato leaf curl New Delhi virus and impacts viral replication in Nicotiana benthamiana · 2022

    Opposite direction

  4. negative
    PsbO, PsbP, PsbQ and PsbR relative expression is significantly reduced at the late stage of TYLCCNV A plus infection

    Tomato Yellow Leaf Curl China Virus Impairs Photosynthesis in the Infected Nicotiana benthamiana with βC1 as an Aggravating Factor · 2019

    Opposite direction

  5. negative
    CREP1 disruption significantly downregulated plant immune defense genes.

    The novel effector CREP1 of endophytic Fusarium lateritium regulates host plant immunity through interaction with receptor protein NbEIX2 · 2026

    Opposite direction

  6. positive
    TLCYnV infection upregulated transcription of autophagy-related genes in Nicotiana benthamiana.

    Geminiviral C2 proteins inhibit active autophagy to facilitate virus infection by impairing the interaction of ATG7 and ATG8 · 2023

    Same direction

  7. positive
    Hsp90 and SGT1 silencing increased PR gene expression in plants challenged with R. solanacearum compared with control plants.

    Molecular chaperons and co-chaperons, Hsp90, RAR1, and SGT1 negatively regulate bacterial wilt disease caused byRalstonia solanacearuminNicotiana benthamiana · 2014 · compared with control plants

    Same direction

  8. positive
    P. parasitica infection induced NbPROPPI1/2 expression.

    The novel peptide NbPPI1 identified from Nicotiana benthamiana triggers immune responses and enhances resistance against Phytophthora pathogens · 2020

    Same direction

1 paper more in this group

See all 10 papers →

Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.