Abstract
• Geminivirus infection activates the upregulation expression of plant microtubule-associated E3 ligase ( MEL ). • MEL promotes the degradation of plant immune negative regulator to resist geminivirus. • MEL specifically recognizes geminivirus-encoded effector V2 protein for poly-ubiquitination and degradation. Geminiviruses mainly infect economically important dicot plants and cause serious damages in agriculture. Here we report that the dicot plant Nicotiana benthamiana microtubule-associated E3 ligase (MEL) plays a dual role in regulating geminivirus infection in N. benthamiana . On the one hand, NbMEL functioned as a defense factor to mediate resistance against geminiviruses with single-stranded, circular DNA genomes by promoting the degradation of plant immune negative regulator. On the other hand, NbMEL could specifically recognize geminivirus-encoded V2 protein, a viral gene silencing suppressor and effector, for polyubiquitination and degradation to suppress geminivirus infection. These findings provide a fundamental basis for utilizing MEL to generate crop for broad-spectrum resistance in dicot plants.
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Claims 3
Claim · model-written summary
Geminivirus infection upregulated MEL expression.
- Taxon
- Nicotiana benthamiana
Nicotiana benthamianat0 - Treatment
- Geminivirus infectione0
- Outcome
- expression of plant microtubule-associated E3 ligase ( MEL )e0
- Direction
- upregulatione0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“Geminivirus infection activates the upregulation expression of plant microtubule-associated E3 ligase ( MEL )”
t0“Nicotiana benthamiana”
Claim · model-written summary
NbMEL promoted degradation of a negative immune regulator and resistance to geminiviruses.
- Taxon
- Nicotiana benthamianaNicotiana benthamianat0
- Interactor
- geminivirusesGeminiviridaee0pathogen
- Gene
- NbMELe0
- Outcome
- resistance against geminivirusese0
- Qualifier
- promoting the degradation of plant immune negative regulatore0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“NbMEL functioned as a defense factor to mediate resistance against geminiviruses with single-stranded, circular DNA genomes by promoting the degradation of plant immune negative regulator”
t0“Nicotiana benthamiana”
Claim · model-written summary
NbMEL recognized V2 for polyubiquitination and degradation, suppressing infection.
- Taxon
- Nicotiana benthamianaNicotiana benthamianat0
- Interactor
- geminivirusGeminiviridaee0pathogen
- Gene
- NbMELe0
- Outcome
- suppress geminivirus infectione0
- Qualifier
- polyubiquitination and degradatione0
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“NbMEL could specifically recognize geminivirus-encoded V2 protein, a viral gene silencing suppressor and effector, for polyubiquitination and degradation to suppress geminivirus infection”
t0“Nicotiana benthamiana”
The same questions in other papers
infection · molecular: expression · Nicotiana benthamianaPositive and negative results
4 papers in the same direction as this paper · 5 in the opposite direction
- negative
- no effect
- negative
6 papers more in this group
See all 10 papers →Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.