Claim · model-written summary
Phosphatidic acid responded early to PVY infection.
- Taxon
- Nicotiana benthamiana
Nicotiana benthamianat0 - Interactor
- Potato virus Y
Potato virus Ye0pathogen - Outcome
- phosphatidic acid (PA)e0
- Qualifier
- early stage of infectione0
Not reportedMaterialGeneCompoundOrgan / stageSecond interactorSecond interactor roleTreatmentComparatorSettingDirectionValue
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“phosphatidic acid (PA) represents a major class of lipids that respond to Potato virus Y (PVY) at an early stage of infection”
t0“Nicotiana benthamiana”
Title
Activation of MAPK-mediated immunity by phosphatidic acid in response to positive-strand RNA viruses
Jiayu Lin; Jinpeng Zhao; Linlin Du; et al. Plant Communications 2023. doi:10.1016/j.xplc.2023.100659
Other claims from this paper (14)
- Mechanism NbPLDα1 was responsible for higher PA during PVY infection.
- Observation NbPLDα1 played an antiviral role.
- Mechanism PVY 6K2 interacted with NbPLDα1 and raised PA levels.
- Mechanism PVY 6K2 recruited NbPLDα1 and PA to viral replication complexes.
- Mechanism PVY 6K2 activated MAPK signaling through NbPLDα1 and PA.
- Mechanism PA bound WIPK/SIPK/NTF4 and prompted WRKY8 phosphorylation.
- Intervention effect Exogenous PA spray activated the MAPK pathway.
- Intervention effect Knockdown of the MEK2-WIPK/SIPK-WRKY8 cascade enhanced PVY genomic RNA accumulation.
- Observation Turnip mosaic virus 6K2 interacted with NbPLDα1.
- Observation Tomato bushy stunt virus p33 interacted with NbPLDα1.
- Observation Turnip mosaic virus 6K2 induced MAPK-mediated immunity.
- Observation Tomato bushy stunt virus p33 induced MAPK-mediated immunity.
- Intervention effect NbPLDα1 loss of function inhibited virus-induced MAPK activation.
- Intervention effect NbPLDα1 loss of function promoted viral RNA accumulation.