Claim · model-written summary
Cys177 and Cys180 mutations attenuated the resistance effect of TaATG6 overexpression.
- Taxon
- wheat
Triticum aestivumt0 - Treatment
- mutation of Cys177 and Cys180e0
- Outcome
- this effecte0
- Direction
- attenuatede0
Not reportedMaterialGeneCompoundOrgan / stageInteractorInteractor roleSecond interactorSecond interactor roleComparatorSettingValueQualifier
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“mutation of Cys177 and Cys180 attenuated this effect”
t0“wheat”
Title
Hydrogen sulfide promotes wheat immunity against stripe rust through TaATG6c persulfidation
Ying Ma; Fangfang Peng; Ran Zhao; et al. Stress Biology 2026. doi:10.1007/s44154-026-00292-7
Other claims from this paper (13)
- Intervention effect Exogenous hydrogen sulfide enhanced wheat resistance to stripe rust pathogen.
- Observation Proteomics identified TaATG6c as a pathogen-responsive hydrogen sulfide target.
- Intervention effect Hydrogen sulfide induced persulfidation at TaATG6c Cys177 and Cys180.
- Method / resource Structural modeling predicted that two site mutations reduced ATG6c binding to ATG14.
- Intervention effect Silencing TaATG6 promoted fungal growth.
- Observation Pst infection induced TaATG6 expression.
- Intervention effect TaATG6 silencing compromised NaHS-mediated resistance.
- Intervention effect Transient TaATG6 overexpression enhanced wheat stripe rust resistance.
- Observation TaATG6c persulfidation was pathogen responsive and dynamic.
- Intervention effect The pathogen responsive persulfidation was abolished in the TaATG6 C177A/C180A mutant.
- Intervention effect Hydrogen sulfide treatment and Pst infection stimulated lipidated ATG8 accumulation.
- Intervention effect TaATG6 silencing largely abolished lipidated ATG8 accumulation.
- Mechanism Authors infer hydrogen sulfide promotes autophagy through TaATG6c persulfidation to enhance wheat resistance.