Claim · model-written summary
The lethal dose (LD50) of the floral-DCM extract in rats was 4472.13 mg/kg BW.
- Taxon
- Neurada procumbens
Neurada procumbenst0 - Outcome
- lethal dose (LD50)e6
- Value
- 4472.13 mg/kg BWe6
- Qualifier
- in ratse6
Not reportedMaterialGeneCompoundOrgan / stageInteractorInteractor roleSecond interactorSecond interactor roleTreatmentComparatorSettingDirection
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
t0“aerial and floral parts of Neurada procumbens extracts”
e6“The toxicity studies revealed that the floral-DCM dose extract was found to be safe up to 2000 mg/kg BW, while its lethal dose (LD50) was found to be 4472.13 mg/kg BW in rats”
Title
Jawaria Aslam; Mirza Imran Shahzad; Hafiz Muhammad Ali; et al. Journal of King Saud University - Science 2023. doi:10.1016/j.jksus.2023.102822
Other claims from this paper (11)
- Observation Total phenolic content of Neurada procumbens ranged from 28.13 to 78.9 GAE mg/g of plant.
- Observation Total flavonoid content of Neurada procumbens ranged from 17.23 to 68.23 RE mg/g of plant.
- Observation Aerial and floral parts of Neurada procumbens contain a significant amount of polyphenolic compounds, including 2,3 di MeO benzoic acid, p-coumaric acid and chlorogenic acid.
- Observation Aerial and floral parts of Neurada procumbens contain a significant amount of polyphenolic compounds, including quercetin dihydrate and t-ferrulic acid.
- Intervention effect Floral-part DCM and n-butanol extracts had higher DPPH antioxidant potential (IC50 < 100 μg/ml) than the aerial part.
- Intervention effect Floral-part DCM and n-butanol extracts had higher FRAP antioxidant potential (IC50 < 55 μg/ml) than the aerial part.
- Observation The dichloromethane floral extract protected 83 % of HRBC from lysis, a significant result.
- Observation The dichloromethane floral extract had an IC50 of 469.6 µg/ml in the HRBC lysis assay.
- Intervention effect A 300 mg/kg dose of DCM floral extract reduced carrageenan-induced paw oedema from 8.51 to 7.65 mm, a highly significant difference.
- Observation The floral-DCM extract was safe up to 2000 mg/kg BW in toxicity studies.
- Recommendation The floral part of Neurada procumbens could be recommended as a safe pharmacological agent.