Claim · model-written summary
TSWV cell-to-cell spread was delayed in ER-defective rhd3.
- Taxon
- Arabidopsis thaliana
Arabidopsis thalianat0 - Material
- rhd3e0
- Treatment
- ER-defective rhd3 mutante0
- Interactor
- TSWV
Orthotospovirus tomatomaculaee0pathogen - Outcome
- TSWV cell-to-cell spreade0
- Direction
- delayede0
Not reportedGeneCompoundOrgan / stageSecond interactorSecond interactor roleComparatorSettingValueQualifier
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“TSWV cell-to-cell spread was delayed in the ER-defective rhd3 mutant, and this reduced viral infection was not due to reduced replication.”
t0“In the Arabidopsis thaliana mutant rhd3 with an impaired ER network, NSm-GFP trafficking was significantly reduced, whereas GFP diffusion was not affected.”
Title
Zhike Feng; Fan Xue; Min Xu; et al. PLoS Pathogens 2016. doi:10.1371/journal.ppat.1005443
Other claims from this paper (12)
- Observation TSWV NSm was physically associated with the ER membrane in Nicotiana benthamiana.
- Observation NSm-GFP moved from single leaf cells into neighboring cells.
- Intervention effect NSm mutations impairing ER association inhibited cell-to-cell trafficking.
- Intervention effect NSm mutations causing mislocalization inhibited cell-to-cell trafficking.
- Intervention effect Pharmacological ER disruption severely inhibited NSm-GFP trafficking.
- Intervention effect Pharmacological ER disruption did not inhibit GFP diffusion.
- Intervention effect NSm-GFP trafficking was significantly reduced in Arabidopsis rhd3.
- Intervention effect GFP diffusion was unaffected in Arabidopsis rhd3.
- Mechanism The ER-to-Golgi secretion pathway was not involved in TSWV NSm intercellular trafficking.
- Mechanism The cytoskeleton transport systems was not involved in TSWV NSm intercellular trafficking.
- Mechanism Reduced viral infection in rhd3 was not due to reduced replication.
- Mechanism ER membrane transport was identified as a direct route for NSm and TSWV movement between cells.