Abstract
Viruses cause many severe diseases in both plants and animals, urging us to explore new antiviral strategies. In their natural reservoirs, viruses live and replicate while causing mild or no symptoms. Some animals, such as bats, are the predicted natural reservoir of multiple viruses, indicating that they possess broad-spectrum antiviral capabilities. Mechanisms of host defenses against viruses are generally studied independently in plants and animals. In this article, we speculate that some antiviral strategies of natural reservoirs are conserved between kingdoms. To verify this hypothesis, we created null mutants of 10-formyltetrahydrofolate synthetase (AtTHFS), an Arabidopsis thaliana homologue of methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 (MTHFD1), which encodes a positive regulator of viral replication in bats. We found that disruption of AtTHFS enhanced plant resistance to three different types of plant viruses, including the tomato spotted wilt virus (TSWV), the cucumber mosaic virus (CMV) and the beet severe curly top virus (BSCTV). These results demonstrate a novel antiviral strategy for plant breeding. We further discuss the approaches used to identify and study natural reservoirs of plant viruses, especially those hosting many viruses, and highlight the possibility of discovering new antiviral strategies from them for plant molecular breeding and antiviral therapy.
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Claims 3
Claim · model-written summary
Disruption of AtTHFS enhanced resistance to tomato spotted wilt virus (TSWV).
- Taxon
- Arabidopsis thaliana
Arabidopsis thalianat0 - Treatment
- disruption of AtTHFSe0
- Interactor
- tomato spotted wilt virus (TSWV)
Orthotospovirus tomatomaculaee0pathogen - Gene
- AtTHFSe0
- Outcome
- plant resistancee0
- Direction
- enhancede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“disruption of AtTHFS enhanced plant resistance to three different types of plant viruses, including the tomato spotted wilt virus (TSWV), the cucumber mosaic virus (CMV) and the beet severe curly top virus (BSCTV).”
t0“an Arabidopsis thaliana homologue”
Claim · model-written summary
Disruption of AtTHFS enhanced resistance to cucumber mosaic virus (CMV).
- Taxon
- Arabidopsis thalianaArabidopsis thalianat0
- Treatment
- disruption of AtTHFSe0
- Interactor
- cucumber mosaic virus (CMV)
cucumber mosaic cucumoviruse0pathogen - Gene
- AtTHFSe0
- Outcome
- plant resistancee0
- Direction
- enhancede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“disruption of AtTHFS enhanced plant resistance to three different types of plant viruses, including the tomato spotted wilt virus (TSWV), the cucumber mosaic virus (CMV) and the beet severe curly top virus (BSCTV).”
t0“an Arabidopsis thaliana homologue”
Claim · model-written summary
Disruption of AtTHFS enhanced resistance to beet severe curly top virus (BSCTV).
- Taxon
- Arabidopsis thalianaArabidopsis thalianat0
- Treatment
- disruption of AtTHFSe0
- Interactor
- beet severe curly top virus (BSCTV)Beet severe curly top viruse0pathogen
- Gene
- AtTHFSe0
- Outcome
- plant resistancee0
- Direction
- enhancede0
Not reportedComparator
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“disruption of AtTHFS enhanced plant resistance to three different types of plant viruses, including the tomato spotted wilt virus (TSWV), the cucumber mosaic virus (CMV) and the beet severe curly top virus (BSCTV).”
t0“an Arabidopsis thaliana homologue”
The same questions in other papers
loss of function · cucumber mosaic cucumovirus · Arabidopsis thaliana (thale cress)Positive and negative results
2 papers in the same direction as this paper · 1 in the opposite direction
- no effect
- positive
- positive
loss of function · Orthotospovirus tomatomaculae · Arabidopsis thaliana (thale cress)Results agree
1 paper in the same direction as this paper
- positive
Claims are grouped by organism, treatment and what was measured or targeted. A paper counts as positive when any of its claims in the group is positive.