Claim · model-written summary
Among the fractions, fraction C showed the highest antiplasmodial activity, followed by fractions B, A and D.
- Taxon
- Haematostaphis barterit0
- Organ / stage
- stem barkt0
- Outcome
- activitye0
- Direction
- higheste0
- Value
- 12.7 ± 0.2 μg/mL; 8.0 ± 1.5 μg/mLe0
- Qualifier
- fraction Ce0
Not reportedMaterialGeneCompoundInteractorInteractor roleSecond interactorSecond interactor roleTreatmentComparatorSetting
Verbatim
t0“stem bark of Haematostaphis barteri Hook.f.”
e0“Among the fractions, fraction C showed the highest activity (12.7 ± 0.2 μg/mL; 8.0 ± 1.5 μg/mL), followed by fraction B, A, and D”
Title
Dé Ndonaï-Koula Lafya Bodeboret Djimtoingar; Jean Noël Nyemb; Hervé Landry Ketsemen; et al. Journal of Ethnopharmacology 2026. doi:10.1016/j.jep.2026.121438
Other claims from this paper (14)
- Observation The crude stem bark extract showed good in vitro antiplasmodial activity against P. falciparum Dd2, IC50 13.0 ± 2.0 μg/mL.
- Observation The crude stem bark extract showed good in vitro antiplasmodial activity against P. falciparum 3D7, IC50 8.6 ± 2.3 μg/mL.
- Observation Six known compounds were isolated from the stem bark extract.
- Observation Compounds 1, 3 and 5 were reported for the first time in the Anacardiaceae family.
- Observation Docking of the isolated compounds toward falcipain-2 yielded modest predicted binding energies of -5.4 to -6.8 kcal/mol.
- Association Docking scores did not show a clear correlation with experimental antiplasmodial activity.
- Mechanism Strong falcipain-2 inhibition is unlikely to be the primary mechanism of the antiplasmodial action.
- Observation Compound 1 showed the most favorable falcipain-2 docking score.
- Observation All samples demonstrated antioxidant activity.
- Observation Compound 1 showed the strongest antioxidant effect in the DPPH assay, IC50 59.6 ± 10.4 μg/mL.
- Observation Compound 1 showed the strongest antioxidant effect in the FRAP assay, IC50 69.1 ± 0.2 μg/mL.
- Observation The isolated compounds showed weak to moderate antiplasmodial activity.
- Observation Compound 1 had the lowest IC50 among the isolated compounds against PfDd2, 31.6 ± 2.9 μM.
- Observation Compound 1 had the lowest IC50 among the isolated compounds against Pf3D7, 22.1 ± 0.1 μM.