Claim · model-written summary
The authors interpret downstream BR signaling proteins as being induced by kinase phosphorylation rather than transcriptional regulation.
- Taxon
- Arabidopsis
Arabidopsist0 - Gene
- various kinasese0
- Outcome
- downstream proteins of BR signalinge0
- Qualifier
- not through transcriptional regulatione0
Not reportedMaterialCompoundOrgan / stageInteractorInteractor roleSecond interactorSecond interactor roleTreatmentComparatorSettingDirectionValue
Organisms pictured · Representative pictures of the matched species, not figures from the paper.
Verbatim
e0“many downstream proteins of BR signaling are induced by phosphorylation via various kinases, not through transcriptional regulation.”
t0“Arabidopsis”
Title
Li-Ling Lin; Chia-Lang Hsu; Chia-Wei Hu; et al. BMC Genomics 2015. doi:10.1186/s12864-015-1753-4
Other claims from this paper (12)
- Method / resource The phosphoproteome analysis identified 1104 phosphorylated peptides from 739 phosphoproteins.
- Observation The same analysis identified 739 unique phosphoproteins.
- Observation Time-dependent GO analysis showed a shift from signaling transduction to morphogenesis and stress response.
- Association Most identified phosphoproteins were strongly connected to known BR signaling components.
- Method / resource Motif-X identified 15 enriched motifs.
- Observation Eleven enriched motifs corresponded to six known kinase families.
- Intervention effect Casein kinase 2 substrates were significantly phosphorylated at the start of BR treatment.
- Intervention effect Mitogen-activated protein kinase substrates were significantly dephosphorylated at the start of BR treatment.
- Observation Time-dependent kinase-substrate networks indicated many substrates downstream of auxin and ABA signals.
- Association Most BR-responsive phosphorylation changes were not driven by gene expression changes.
- Observation The study deciphered a kinase-centered network related to BR-regulated growth.
- Observation The identified phosphoproteins and phosphosites provide a dataset for BR signaling studies.